Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

KEY CLINICAL MESSAGE: Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hemat...

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Detalles Bibliográficos
Autores principales: Xiang, Zhifu, Kaur, Varinder, Aburiziq, Ibrahim K, Mehta, Paulette, Emanuel, Peter, Schichman, Steven A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270708/
https://www.ncbi.nlm.nih.gov/pubmed/25548628
http://dx.doi.org/10.1002/ccr3.110

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