HCV 3a Core Protein Increases Lipid Droplet Cholesteryl Ester Content via a Mechanism Dependent on Sphingolipid Biosynthesis

Hepatitis C virus (HCV) infected patients often develop steatosis and the HCV core protein alone can induce this phenomenon. To gain new insights into the pathways leading to steatosis, we performed lipidomic profiling of HCV core protein expressing-Huh-7 cells and also assessed the lipid profile of...

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Detalles Bibliográficos
Autores principales: Loizides-Mangold, Ursula, Clément, Sophie, Alfonso-Garcia, Alba, Branche, Emilie, Conzelmann, Stéphanie, Parisot, Clotilde, Potma, Eric O., Riezman, Howard, Negro, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270764/
https://www.ncbi.nlm.nih.gov/pubmed/25522003
http://dx.doi.org/10.1371/journal.pone.0115309

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