Intrinsic disorder drives N-terminal ubiquitination by Ube2w

Ubiquitination of the αN-terminus of protein substrates has been reported sporadically over the past twenty years. However the identity of an enzyme responsible for this unique ubiquitin (Ub) modification has only recently been elucidated. We show the ubiquitin-conjugating enzyme (E2) Ube2w employs...

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Detalles Bibliográficos
Autores principales: Vittal, Vinayak, Shi, Lei, Wenzel, Dawn M., Scaglione, K. Matthew, Duncan, Emily D., Basrur, Venkatesha, Elenitoba-Johnson, Kojo S. J., Baker, David, Paulson, Henry L., Brzovic, Peter S., Klevit, Rachel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270946/
https://www.ncbi.nlm.nih.gov/pubmed/25436519
http://dx.doi.org/10.1038/nchembio.1700

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