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The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases

BACKGROUND: Among the proteinuric patients with chronic kidney disease (CKD) who undergo a renal biopsy, we sometimes encounter those who cannot be classified as having a known primary or secondary glomerular disease. The pathogenesis and pathophysiology of these CKD patients have not been sufficien...

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Autores principales: Okamoto, Hidekazu, Kawamura, Tetsuya, Okonogi, Hideo, Tsuboi, Nobuo, Miyazaki, Yoichi, Yokoo, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271132/
https://www.ncbi.nlm.nih.gov/pubmed/24509731
http://dx.doi.org/10.1007/s10157-014-0940-y
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author Okamoto, Hidekazu
Kawamura, Tetsuya
Okonogi, Hideo
Tsuboi, Nobuo
Miyazaki, Yoichi
Yokoo, Takashi
author_facet Okamoto, Hidekazu
Kawamura, Tetsuya
Okonogi, Hideo
Tsuboi, Nobuo
Miyazaki, Yoichi
Yokoo, Takashi
author_sort Okamoto, Hidekazu
collection PubMed
description BACKGROUND: Among the proteinuric patients with chronic kidney disease (CKD) who undergo a renal biopsy, we sometimes encounter those who cannot be classified as having a known primary or secondary glomerular disease. The pathogenesis and pathophysiology of these CKD patients have not been sufficiently elucidated. METHODS: We recruited 34 proteinuric patients without known glomerular diseases. The glomerular volumes (GV) of the biopsy specimens from those patients were determined by a morphometric analysis. Glomerular hypertrophy (GH) was defined as having more than 3.6 × 10(6) μm(3). The patients were divided in two groups: those with GH (Group 1) and those without GH (Group 2). We compared the clinical and pathological parameters between Group 1 and Group 2, and among the three groups of patients: non-obese, overweight and obese group. RESULTS: The patients with Group 1 had significantly higher values for the proportion of males, the body mass index (BMI), uric acid and significantly lower values for the glomerular density (GD). Of note, a multivariate regression analysis revealed that sex, the BMI and GD were significant factors correlated with the mean GV. The values for the mean GV were significantly higher in the overweight and obese groups as compared to the non-obese group, and the values for the GD were significantly lower in the obese group than in the non-obese group. CONCLUSIONS: We identified a subgroup of patients who were characterized as having a high BMI and GV, and a low GD among the proteinuric CKD patients without known glomerular diseases.
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spelling pubmed-42711322014-12-22 The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases Okamoto, Hidekazu Kawamura, Tetsuya Okonogi, Hideo Tsuboi, Nobuo Miyazaki, Yoichi Yokoo, Takashi Clin Exp Nephrol Original Article BACKGROUND: Among the proteinuric patients with chronic kidney disease (CKD) who undergo a renal biopsy, we sometimes encounter those who cannot be classified as having a known primary or secondary glomerular disease. The pathogenesis and pathophysiology of these CKD patients have not been sufficiently elucidated. METHODS: We recruited 34 proteinuric patients without known glomerular diseases. The glomerular volumes (GV) of the biopsy specimens from those patients were determined by a morphometric analysis. Glomerular hypertrophy (GH) was defined as having more than 3.6 × 10(6) μm(3). The patients were divided in two groups: those with GH (Group 1) and those without GH (Group 2). We compared the clinical and pathological parameters between Group 1 and Group 2, and among the three groups of patients: non-obese, overweight and obese group. RESULTS: The patients with Group 1 had significantly higher values for the proportion of males, the body mass index (BMI), uric acid and significantly lower values for the glomerular density (GD). Of note, a multivariate regression analysis revealed that sex, the BMI and GD were significant factors correlated with the mean GV. The values for the mean GV were significantly higher in the overweight and obese groups as compared to the non-obese group, and the values for the GD were significantly lower in the obese group than in the non-obese group. CONCLUSIONS: We identified a subgroup of patients who were characterized as having a high BMI and GV, and a low GD among the proteinuric CKD patients without known glomerular diseases. Springer Japan 2014-02-11 2014 /pmc/articles/PMC4271132/ /pubmed/24509731 http://dx.doi.org/10.1007/s10157-014-0940-y Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Okamoto, Hidekazu
Kawamura, Tetsuya
Okonogi, Hideo
Tsuboi, Nobuo
Miyazaki, Yoichi
Yokoo, Takashi
The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases
title The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases
title_full The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases
title_fullStr The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases
title_full_unstemmed The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases
title_short The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases
title_sort role of a low glomerular density and being overweight in the etiology of proteinuria in ckd patients without known glomerular diseases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271132/
https://www.ncbi.nlm.nih.gov/pubmed/24509731
http://dx.doi.org/10.1007/s10157-014-0940-y
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