BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid

BACKGROUND: The recently discovered small-molecule BI-2 potently blocks HIV-1 infection. BI-2 binds to the N-terminal domain of HIV-1 capsid. BI-2 utilizes the same capsid pocket used by the small molecule PF74. Although both drugs bind to the same pocket, it has been proposed that BI-2 uses a diffe...

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Detalles Bibliográficos
Autores principales: Fricke, Thomas, Buffone, Cindy, Opp, Silvana, Valle-Casuso, Jose, Diaz-Griffero, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271331/
https://www.ncbi.nlm.nih.gov/pubmed/25496772
http://dx.doi.org/10.1186/s12977-014-0120-x

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