Chemical chaperone 4-phenylbutyrate prevents endoplasmic reticulum stress induced by T17M rhodopsin

BACKGROUND: Rhodopsin mutations are associated with the autosomal dominant form of retinitis pigmentosa. T17M mutation in rhodopsin predisposes cells to endoplasmic reticulum (ER) stress and induces cell death. This study aimed to examine whether chemical chaperone 4-phenylbutyrate prevents ER stres...

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Detalles Bibliográficos
Autores principales: Jiang, Haibo, Xiong, Siqi, Xia, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271335/
https://www.ncbi.nlm.nih.gov/pubmed/25530840
http://dx.doi.org/10.1186/2045-3701-4-75

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