NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors

BACKGROUND: T-type calcium channels and cannabinoid receptors are known to play important roles in chronic pain, making them attractive therapeutic targets. We recently reported on the design, synthesis and analgesic properties of a novel T-type channel inhibitor (NMP-7), which also shows mixed agon...

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Detalles Bibliográficos
Autores principales: Berger, N Daniel, Gadotti, Vinicius M, Petrov, Ravil R, Chapman, Kevin, Diaz, Philippe, Zamponi, Gerald W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271433/
https://www.ncbi.nlm.nih.gov/pubmed/25481027
http://dx.doi.org/10.1186/1744-8069-10-77

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