A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1

BACKGROUND: Previously we described a transdominant negative mutant of the HIV-1 Tat protein, termed Nullbasic, that downregulated the steady state levels of unspliced and singly spliced viral mRNA, an activity caused by inhibition of HIV-1 Rev activity. Nullbasic also altered the subcellular locali...

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Detalles Bibliográficos
Autores principales: Lin, Min-Hsuan, Sivakumaran, Haran, Jones, Alun, Li, Dongsheng, Harper, Callista, Wei, Ting, Jin, Hongping, Rustanti, Lina, Meunier, Frederic A, Spann, Kirsten, Harrich, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271445/
https://www.ncbi.nlm.nih.gov/pubmed/25496916
http://dx.doi.org/10.1186/s12977-014-0121-9

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