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Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1

Kallikrein-6 and calpain-1 are amongst a small group of proteases that degrade α-synuclein. We have explored the possibility that reduction in the level or activity of these enzymes contributes to the accumulation of α-synuclein in Lewy body diseases. We measured calpain-1 activity by fluorogenic ac...

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Detalles Bibliográficos
Autores principales:	Miners, J Scott, Renfrew, Ruth, Swirski, Marta, Love, Seth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271448/ https://www.ncbi.nlm.nih.gov/pubmed/25476568 http://dx.doi.org/10.1186/s40478-014-0164-0

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