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Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012

BACKGROUND: Manganese is an essential element, but excessive manganese exposure has neurotoxic effects. OBJECTIVE: To examine blood manganese levels in the general population with respect to sex, age, race/ethnicity, pregnancy and menauposal status, as well as levels of trace elements in blood. METH...

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Autores principales: Oulhote, Youssef, Mergler, Donna, Bouchard, Maryse F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271487/
https://www.ncbi.nlm.nih.gov/pubmed/25342305
http://dx.doi.org/10.1186/1476-069X-13-87
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author Oulhote, Youssef
Mergler, Donna
Bouchard, Maryse F
author_facet Oulhote, Youssef
Mergler, Donna
Bouchard, Maryse F
author_sort Oulhote, Youssef
collection PubMed
description BACKGROUND: Manganese is an essential element, but excessive manganese exposure has neurotoxic effects. OBJECTIVE: To examine blood manganese levels in the general population with respect to sex, age, race/ethnicity, pregnancy and menauposal status, as well as levels of trace elements in blood. METHODS: We used data from the National Health and Nutrition Examination Survey, a national survey of U.S. residents (n = 7720 participants, ages 1 to 80 years). General linear models and generalized additive models were used to examine the association between blood manganese concentration and participants’ characterisics, accounting for the complex survey design. RESULTS: Blood manganese levels ranged from 1.6 to 62.5 μg/L, with arithmetic means of 10.6 and 9.2 μg/L for women and men, respectively. The following characteristics were significantly associated with higher blood manganese levels: female sex, younger age, Asian origin, and being pregnant. In addition, there were non-linear relationships between blood manganese levels and cadmium, iron, lead, and mercury levels. CONCLUSION: The higher blood manganese levels observed among females suggest sex-related metabolic differences in the regulation of manganese, and elevated levels among pregnant women suggest an important role of manganese in reproduction. The present study supports the need to take into consideration age- and sex-related differences in blood manganese levels, as well as pregnancy status when examining manganese essentiality or toxicity.
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spelling pubmed-42714872014-12-20 Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012 Oulhote, Youssef Mergler, Donna Bouchard, Maryse F Environ Health Research BACKGROUND: Manganese is an essential element, but excessive manganese exposure has neurotoxic effects. OBJECTIVE: To examine blood manganese levels in the general population with respect to sex, age, race/ethnicity, pregnancy and menauposal status, as well as levels of trace elements in blood. METHODS: We used data from the National Health and Nutrition Examination Survey, a national survey of U.S. residents (n = 7720 participants, ages 1 to 80 years). General linear models and generalized additive models were used to examine the association between blood manganese concentration and participants’ characterisics, accounting for the complex survey design. RESULTS: Blood manganese levels ranged from 1.6 to 62.5 μg/L, with arithmetic means of 10.6 and 9.2 μg/L for women and men, respectively. The following characteristics were significantly associated with higher blood manganese levels: female sex, younger age, Asian origin, and being pregnant. In addition, there were non-linear relationships between blood manganese levels and cadmium, iron, lead, and mercury levels. CONCLUSION: The higher blood manganese levels observed among females suggest sex-related metabolic differences in the regulation of manganese, and elevated levels among pregnant women suggest an important role of manganese in reproduction. The present study supports the need to take into consideration age- and sex-related differences in blood manganese levels, as well as pregnancy status when examining manganese essentiality or toxicity. BioMed Central 2014-10-24 /pmc/articles/PMC4271487/ /pubmed/25342305 http://dx.doi.org/10.1186/1476-069X-13-87 Text en © Oulhote et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Oulhote, Youssef
Mergler, Donna
Bouchard, Maryse F
Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012
title Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012
title_full Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012
title_fullStr Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012
title_full_unstemmed Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012
title_short Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012
title_sort sex- and age-differences in blood manganese levels in the u.s. general population: national health and nutrition examination survey 2011–2012
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271487/
https://www.ncbi.nlm.nih.gov/pubmed/25342305
http://dx.doi.org/10.1186/1476-069X-13-87
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