Expression Profile and Gene Age Jointly Shaped the Genome-Wide Distribution of Premature Termination Codons in a Drosophila melanogaster Population

Widespread premature termination codon mutations (PTCs) were recently observed in human and fly populations. We took advantage of the population resequencing data in the Drosophila Genetic Reference Panel to investigate how the expression profile and the evolutionary age of genes shaped the allele f...

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Detalles Bibliográficos
Autores principales: Yang, Haiwang, He, Bin Z., Ma, Huijing, Tsaur, Shun-Chern, Ma, Chenyu, Wu, Ying, Ting, Chau-Ti, Zhang, Yong E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271532/
https://www.ncbi.nlm.nih.gov/pubmed/25371429
http://dx.doi.org/10.1093/molbev/msu299

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