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A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-Disposition

Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are key components on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes (CTLs). Coding single nucleotide polymorphisms (SNPs) in these enzymes have been associated with pre-disposition to several m...

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Detalles Bibliográficos
Autores principales:	Stratikos, Efstratios, Stamogiannos, Athanasios, Zervoudi, Efthalia, Fruci, Doriana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271575/ https://www.ncbi.nlm.nih.gov/pubmed/25566501 http://dx.doi.org/10.3389/fonc.2014.00363

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