GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder in humans characterized by progressive degeneration of skeletal muscle and motor neurons in spinal cord, brainstem, and cerebral cortex causing skeletal muscle paralysis, respiratory insufficiency, and death. There are no cures or...

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Detalles Bibliográficos
Autores principales: Martin, Lee J., Fancelli, Daniele, Wong, Margaret, Niedzwiecki, Mark, Ballarini, Marco, Plyte, Simon, Chang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271619/
https://www.ncbi.nlm.nih.gov/pubmed/25565966
http://dx.doi.org/10.3389/fncel.2014.00433

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