Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin. Consequently, their preferential integration in transcribed genes raises several conceptual and safety issues. To a...

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Detalles Bibliográficos
Autores principales: Qamar Saeed, Muhammad, Dufour, Noelle, Bartholmae, Cynthia, Sieranska, Urzula, Knopf, Malaika, Thierry, Eloïse, Thierry, Sylvain, Delelis, Olivier, Grandchamp, Nicolas, Pilet, Héloïse, Ravassard, Philippe, Massonneau, Julie, Pflumio, Françoise, von Kalle, Christof, Lachapelle, François, Bemelmans, Alexis-Pierre, Schmidt, Manfred, Serguera, Ché
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272407/
https://www.ncbi.nlm.nih.gov/pubmed/25462529
http://dx.doi.org/10.1038/mtna.2014.65

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