Correlation of Age and Severity of Clinical Manifestation Assessed by UPDRS in Patients with Idiopathic Parkinson's Disease

AIM: in older people with Parkinson's disease the symptoms are more expressed. BACKGROUND: Essential change in Parkinson's disease is the impaired neurotransmission in basal ganglia. Idiopathic Parkinson's disease (IPD) is the most frequent type of Parkinsonism, being present in about 70% of the patients with Parkinsonism. MATERIAL AND METHODS: This study has been prospective, clinically one, which has been lasting for whole 2 years. This study comprised a total of 32 subjects with clinically verified diagnosis for idiopathic Parkinson's disease, 18 men and 14 women (with mean age of 52,7 years). Control group consisted of 31 randomly selected, literally healthy persons, at similar age, with similar gender representation without clinical and anamnestic data for Parkinsonism and similar clinical entities. This study was made at the University Clinic of Neurology in Skopje, Medical Faculty, University “St. Cyril and Methodius”. The persons investigated had idiopathic Parkinson's disease (IPD), in whom IPD was verified by means of detailed anamnesis, detailed clinical neurologic examination, strictly keeping to Brain Bank Criteria, and by means of neurophysiologic investigations, neuroimaging investigations and neuropsychologic investigations. Minimal symptoms of IPD after UPDRS were present in 34,4% of the examinees, there were 40,6% with slight signs, while equal number of the examinees 4 (12,5%) had pronounce and very expressed symptoms of Parkinson's disease after UPDRS. CONCLUSION: Parkinson's disease is with more expressed signs and symptoms and with slight symptoms in older patients with this diagnosis.