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The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

BACKGROUND: The outcome of a viral infection is regulated by complex interactions of viral and host factors. SARS coronavirus (SARS-CoV) engages and regulates several innate immune response pathways during infection. We have previously shown that the SARS-CoV Papain-like Protease (PLpro) inhibits ty...

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Detalles Bibliográficos
Autores principales:	Matthews, Krystal, Schäfer, Alexandra, Pham, Alissa, Frieman, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272517/ https://www.ncbi.nlm.nih.gov/pubmed/25481026 http://dx.doi.org/10.1186/s12985-014-0209-9

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