A polymethoxyflavone from Laggera pterodonta induces apoptosis in imatinib-resistant K562R cells via activation of the intrinsic apoptosis pathway

BACKGROUND: Treatment with imatinib mesylate (IM) (a tyrosine kinase inhibitor) is the first line of standard care for patients newly diagnosed with CML. Despite the success of IM and other tyrosine kinase inhibitors (TKIs), chronic myeloid leukemia (CML) remains largely incurable, and a number of C...

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Detalles Bibliográficos
Autores principales: Cao, Changshu, Liu, Bailian, Zeng, Chengwu, Lu, Yuhong, Chen, Shaohua, Yang, Lijian, Li, Bo, Li, Yaolan, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272561/
https://www.ncbi.nlm.nih.gov/pubmed/25530716
http://dx.doi.org/10.1186/s12935-014-0137-1

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