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Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats

Tacrolimus (Tac) is a core immunosuppressive drug in human organ transplantation. In feline kidney transplantation, however, the cost of Tac therapy is a significant obstacle. Clarithromycin (CLM) increases the blood trough level of Tac, effectively reducing the Tac dosage in human transplant patien...

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Autores principales: KATAYAMA, Masaaki, USHIO, Taku, SHIMAMURA, Shunsuke, OKAMURA, Yasuhiko, UZUKA, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272988/
https://www.ncbi.nlm.nih.gov/pubmed/25099737
http://dx.doi.org/10.1292/jvms.14-0101
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author KATAYAMA, Masaaki
USHIO, Taku
SHIMAMURA, Shunsuke
OKAMURA, Yasuhiko
UZUKA, Yuji
author_facet KATAYAMA, Masaaki
USHIO, Taku
SHIMAMURA, Shunsuke
OKAMURA, Yasuhiko
UZUKA, Yuji
author_sort KATAYAMA, Masaaki
collection PubMed
description Tacrolimus (Tac) is a core immunosuppressive drug in human organ transplantation. In feline kidney transplantation, however, the cost of Tac therapy is a significant obstacle. Clarithromycin (CLM) increases the blood trough level of Tac, effectively reducing the Tac dosage in human transplant patients. The interaction between CLM and Tac in cats has not been reported. In this study, the effect of multiple CLM dosing on the pharmacokinetics of Tac in three healthy cats was investigated. The treatments included Tac at 0.3 mg/kg and Tac at 0.3 mg/kg + multiple-dose CLM at 10 mg/kg. Co-administration of CLM and Tac resulted in significant increases in the oral bioavailability of Tac. These preliminary findings suggest that administration of multiple doses of CLM may decrease the required Tac dosage in Tac-based immunosuppressive therapy used as an alternative to the classic cyclosporine-based protocol for feline renal transplantation.
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spelling pubmed-42729882015-01-08 Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats KATAYAMA, Masaaki USHIO, Taku SHIMAMURA, Shunsuke OKAMURA, Yasuhiko UZUKA, Yuji J Vet Med Sci Surgery Tacrolimus (Tac) is a core immunosuppressive drug in human organ transplantation. In feline kidney transplantation, however, the cost of Tac therapy is a significant obstacle. Clarithromycin (CLM) increases the blood trough level of Tac, effectively reducing the Tac dosage in human transplant patients. The interaction between CLM and Tac in cats has not been reported. In this study, the effect of multiple CLM dosing on the pharmacokinetics of Tac in three healthy cats was investigated. The treatments included Tac at 0.3 mg/kg and Tac at 0.3 mg/kg + multiple-dose CLM at 10 mg/kg. Co-administration of CLM and Tac resulted in significant increases in the oral bioavailability of Tac. These preliminary findings suggest that administration of multiple doses of CLM may decrease the required Tac dosage in Tac-based immunosuppressive therapy used as an alternative to the classic cyclosporine-based protocol for feline renal transplantation. The Japanese Society of Veterinary Science 2014-08-05 2014-11 /pmc/articles/PMC4272988/ /pubmed/25099737 http://dx.doi.org/10.1292/jvms.14-0101 Text en ©2014 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Surgery
KATAYAMA, Masaaki
USHIO, Taku
SHIMAMURA, Shunsuke
OKAMURA, Yasuhiko
UZUKA, Yuji
Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats
title Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats
title_full Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats
title_fullStr Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats
title_full_unstemmed Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats
title_short Preliminary Study of Interaction of Clarithromycin with Tacrolimus in Cats
title_sort preliminary study of interaction of clarithromycin with tacrolimus in cats
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272988/
https://www.ncbi.nlm.nih.gov/pubmed/25099737
http://dx.doi.org/10.1292/jvms.14-0101
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