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Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey

We aimed to estimate the cutoff value of glycated hemoglobin (HbA1c, A1c) for fasting plasma glucose (FPG) of 126 mg/dL in the Korean adult population, using the 2011 Korea National Health and Nutrition Examination Survey. A total of 5,421 participants without a history of diabetes and over 19 years...

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Autores principales: Kim, Jung Min, Hong, Jae Won, Won, Jong Chul, Noh, Jung Hyun, Ko, Kyung Soo, Rhee, Byoung Doo, Kim, Dong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273035/
https://www.ncbi.nlm.nih.gov/pubmed/25541612
http://dx.doi.org/10.4093/dmj.2014.38.6.480
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author Kim, Jung Min
Hong, Jae Won
Won, Jong Chul
Noh, Jung Hyun
Ko, Kyung Soo
Rhee, Byoung Doo
Kim, Dong-Jun
author_facet Kim, Jung Min
Hong, Jae Won
Won, Jong Chul
Noh, Jung Hyun
Ko, Kyung Soo
Rhee, Byoung Doo
Kim, Dong-Jun
author_sort Kim, Jung Min
collection PubMed
description We aimed to estimate the cutoff value of glycated hemoglobin (HbA1c, A1c) for fasting plasma glucose (FPG) of 126 mg/dL in the Korean adult population, using the 2011 Korea National Health and Nutrition Examination Survey. A total of 5,421 participants without a history of diabetes and over 19 years of age were included in the analysis. A point-wise area under the receiver operating characteristic curve was used to estimate the optimal A1c cutoff value. A1c threshold of 6.1% produced the highest sum of sensitivity (85.2%) and specificity (90.5%) for FPG of 126 mg/dL (area under the curve, 0.941, P<0.001). A1c of 6.5% produced a sensitivity of 67.7% and specificity of 98.0% for FPG of 126 mg/dL. Considering A1c as one of three criteria for the diagnosis of diabetes and the specificity of an A1c cutoff of 6.5%, the current diagnostic criteria of A1c≥6.5% might be acceptable in the Korean adult population.
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spelling pubmed-42730352014-12-25 Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey Kim, Jung Min Hong, Jae Won Won, Jong Chul Noh, Jung Hyun Ko, Kyung Soo Rhee, Byoung Doo Kim, Dong-Jun Diabetes Metab J Brief Report We aimed to estimate the cutoff value of glycated hemoglobin (HbA1c, A1c) for fasting plasma glucose (FPG) of 126 mg/dL in the Korean adult population, using the 2011 Korea National Health and Nutrition Examination Survey. A total of 5,421 participants without a history of diabetes and over 19 years of age were included in the analysis. A point-wise area under the receiver operating characteristic curve was used to estimate the optimal A1c cutoff value. A1c threshold of 6.1% produced the highest sum of sensitivity (85.2%) and specificity (90.5%) for FPG of 126 mg/dL (area under the curve, 0.941, P<0.001). A1c of 6.5% produced a sensitivity of 67.7% and specificity of 98.0% for FPG of 126 mg/dL. Considering A1c as one of three criteria for the diagnosis of diabetes and the specificity of an A1c cutoff of 6.5%, the current diagnostic criteria of A1c≥6.5% might be acceptable in the Korean adult population. Korean Diabetes Association 2014-12 2014-12-15 /pmc/articles/PMC4273035/ /pubmed/25541612 http://dx.doi.org/10.4093/dmj.2014.38.6.480 Text en Copyright © 2014 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Kim, Jung Min
Hong, Jae Won
Won, Jong Chul
Noh, Jung Hyun
Ko, Kyung Soo
Rhee, Byoung Doo
Kim, Dong-Jun
Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey
title Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey
title_full Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey
title_fullStr Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey
title_full_unstemmed Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey
title_short Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey
title_sort glycated hemoglobin value for fasting plasma glucose of 126 mg/dl in korean: the 2011 korea national health and nutrition examination survey
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273035/
https://www.ncbi.nlm.nih.gov/pubmed/25541612
http://dx.doi.org/10.4093/dmj.2014.38.6.480
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