Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery

Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigenc...

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Detalles Bibliográficos
Autores principales: Fernández-Ferreiro, Anxo, Fernández Bargiela, Noelia, Varela, María Santiago, Martínez, Maria Gil, Pardo, Maria, Piñeiro Ces, Antonio, Méndez, José Blanco, Barcia, Miguel González, Lamas, Maria Jesus, Otero-Espinar, FranciscoJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273241/
https://www.ncbi.nlm.nih.gov/pubmed/25550757
http://dx.doi.org/10.3762/bjoc.10.308
Descripción
Sumario:Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole–HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.

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