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Inherently chiral calix[4]arenes via oxazoline directed ortholithiation: synthesis and probe of chiral space

The diastereoselective oxazoline-directed lithiation of calix[4]arenes is reported with diastereoselective ratios of greater than 100:1 in some instances. Notably, it has been found that the opposite diastereomer can be accessed via this approach merely through the choice of an alkyllithium reagent....

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Detalles Bibliográficos
Autores principales: Herbert, Simon A, van Laeren, Laura J, Castell, Dominic C, Arnott, Gareth E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273304/
https://www.ncbi.nlm.nih.gov/pubmed/25550740
http://dx.doi.org/10.3762/bjoc.10.291
Descripción
Sumario:The diastereoselective oxazoline-directed lithiation of calix[4]arenes is reported with diastereoselective ratios of greater than 100:1 in some instances. Notably, it has been found that the opposite diastereomer can be accessed via this approach merely through the choice of an alkyllithium reagent. The inherently chiral oxazoline calix[4]arenes have also been preliminarily examined as ligands in the palladium-catalyzed Tsuji–Trost allylation reaction, returning results comparable to their planar chiral ferrocene counterparts pointing towards future application of these types of compounds.