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Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila
Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by ∼2000 Kenyon cells, which converge onto 34 output neurons (MBONs) of 21 t...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273436/ https://www.ncbi.nlm.nih.gov/pubmed/25535794 http://dx.doi.org/10.7554/eLife.04580 |
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author | Aso, Yoshinori Sitaraman, Divya Ichinose, Toshiharu Kaun, Karla R Vogt, Katrin Belliart-Guérin, Ghislain Plaçais, Pierre-Yves Robie, Alice A Yamagata, Nobuhiro Schnaitmann, Christopher Rowell, William J Johnston, Rebecca M Ngo, Teri-T B Chen, Nan Korff, Wyatt Nitabach, Michael N Heberlein, Ulrike Preat, Thomas Branson, Kristin M Tanimoto, Hiromu Rubin, Gerald M |
author_facet | Aso, Yoshinori Sitaraman, Divya Ichinose, Toshiharu Kaun, Karla R Vogt, Katrin Belliart-Guérin, Ghislain Plaçais, Pierre-Yves Robie, Alice A Yamagata, Nobuhiro Schnaitmann, Christopher Rowell, William J Johnston, Rebecca M Ngo, Teri-T B Chen, Nan Korff, Wyatt Nitabach, Michael N Heberlein, Ulrike Preat, Thomas Branson, Kristin M Tanimoto, Hiromu Rubin, Gerald M |
author_sort | Aso, Yoshinori |
collection | PubMed |
description | Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by ∼2000 Kenyon cells, which converge onto 34 output neurons (MBONs) of 21 types. We studied the role of MBONs in several associative learning tasks and in sleep regulation, revealing the extent to which information flow is segregated into distinct channels and suggesting possible roles for the multi-layered MBON network. We also show that optogenetic activation of MBONs can, depending on cell type, induce repulsion or attraction in flies. The behavioral effects of MBON perturbation are combinatorial, suggesting that the MBON ensemble collectively represents valence. We propose that local, stimulus-specific dopaminergic modulation selectively alters the balance within the MBON network for those stimuli. Our results suggest that valence encoded by the MBON ensemble biases memory-based action selection. DOI: http://dx.doi.org/10.7554/eLife.04580.001 |
format | Online Article Text |
id | pubmed-4273436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42734362015-01-29 Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila Aso, Yoshinori Sitaraman, Divya Ichinose, Toshiharu Kaun, Karla R Vogt, Katrin Belliart-Guérin, Ghislain Plaçais, Pierre-Yves Robie, Alice A Yamagata, Nobuhiro Schnaitmann, Christopher Rowell, William J Johnston, Rebecca M Ngo, Teri-T B Chen, Nan Korff, Wyatt Nitabach, Michael N Heberlein, Ulrike Preat, Thomas Branson, Kristin M Tanimoto, Hiromu Rubin, Gerald M eLife Neuroscience Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by ∼2000 Kenyon cells, which converge onto 34 output neurons (MBONs) of 21 types. We studied the role of MBONs in several associative learning tasks and in sleep regulation, revealing the extent to which information flow is segregated into distinct channels and suggesting possible roles for the multi-layered MBON network. We also show that optogenetic activation of MBONs can, depending on cell type, induce repulsion or attraction in flies. The behavioral effects of MBON perturbation are combinatorial, suggesting that the MBON ensemble collectively represents valence. We propose that local, stimulus-specific dopaminergic modulation selectively alters the balance within the MBON network for those stimuli. Our results suggest that valence encoded by the MBON ensemble biases memory-based action selection. DOI: http://dx.doi.org/10.7554/eLife.04580.001 eLife Sciences Publications, Ltd 2014-12-23 /pmc/articles/PMC4273436/ /pubmed/25535794 http://dx.doi.org/10.7554/eLife.04580 Text en © 2014, Aso et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Aso, Yoshinori Sitaraman, Divya Ichinose, Toshiharu Kaun, Karla R Vogt, Katrin Belliart-Guérin, Ghislain Plaçais, Pierre-Yves Robie, Alice A Yamagata, Nobuhiro Schnaitmann, Christopher Rowell, William J Johnston, Rebecca M Ngo, Teri-T B Chen, Nan Korff, Wyatt Nitabach, Michael N Heberlein, Ulrike Preat, Thomas Branson, Kristin M Tanimoto, Hiromu Rubin, Gerald M Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila |
title | Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila |
title_full | Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila |
title_fullStr | Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila |
title_full_unstemmed | Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila |
title_short | Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila |
title_sort | mushroom body output neurons encode valence and guide memory-based action selection in drosophila |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273436/ https://www.ncbi.nlm.nih.gov/pubmed/25535794 http://dx.doi.org/10.7554/eLife.04580 |
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