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Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review
Background. Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. Methods. We identified 3 patients presenting with MPNST of t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273476/ https://www.ncbi.nlm.nih.gov/pubmed/25548703 http://dx.doi.org/10.1155/2014/368920 |
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author | Mullins, Brandon T. Hackman, Trevor |
author_facet | Mullins, Brandon T. Hackman, Trevor |
author_sort | Mullins, Brandon T. |
collection | PubMed |
description | Background. Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. Methods. We identified 3 patients presenting with MPNST of the head and neck and treated at the University of North Carolina. We compared our results to the literature from 1963 to 2014. Results. Mean follow-up was 31 months. Average age at diagnosis was 44.7 years of age. All patients received wide-local excision and adjuvant radiotherapy. No patients recurred during the series. Recurrence-free survival time for the patients was 45, 37, and 3 months, respectively. Conclusions. Our data series confirms that a combined-modality approach with complete surgical resection and adjuvant radiotherapy leads to improved outcomes in MPNSTs of the head and neck. Nonetheless, due to historically poor outcomes, continued research into newer therapies needs to be explored. |
format | Online Article Text |
id | pubmed-4273476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42734762014-12-29 Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review Mullins, Brandon T. Hackman, Trevor Case Rep Otolaryngol Case Report Background. Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. Methods. We identified 3 patients presenting with MPNST of the head and neck and treated at the University of North Carolina. We compared our results to the literature from 1963 to 2014. Results. Mean follow-up was 31 months. Average age at diagnosis was 44.7 years of age. All patients received wide-local excision and adjuvant radiotherapy. No patients recurred during the series. Recurrence-free survival time for the patients was 45, 37, and 3 months, respectively. Conclusions. Our data series confirms that a combined-modality approach with complete surgical resection and adjuvant radiotherapy leads to improved outcomes in MPNSTs of the head and neck. Nonetheless, due to historically poor outcomes, continued research into newer therapies needs to be explored. Hindawi Publishing Corporation 2014 2014-12-04 /pmc/articles/PMC4273476/ /pubmed/25548703 http://dx.doi.org/10.1155/2014/368920 Text en Copyright © 2014 B. T. Mullins and T. Hackman. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Mullins, Brandon T. Hackman, Trevor Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review |
title | Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review |
title_full | Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review |
title_fullStr | Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review |
title_full_unstemmed | Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review |
title_short | Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review |
title_sort | malignant peripheral nerve sheath tumors of the head and neck: a case series and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273476/ https://www.ncbi.nlm.nih.gov/pubmed/25548703 http://dx.doi.org/10.1155/2014/368920 |
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