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Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review

Background. Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. Methods. We identified 3 patients presenting with MPNST of t...

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Autores principales: Mullins, Brandon T., Hackman, Trevor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273476/
https://www.ncbi.nlm.nih.gov/pubmed/25548703
http://dx.doi.org/10.1155/2014/368920
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author Mullins, Brandon T.
Hackman, Trevor
author_facet Mullins, Brandon T.
Hackman, Trevor
author_sort Mullins, Brandon T.
collection PubMed
description Background. Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. Methods. We identified 3 patients presenting with MPNST of the head and neck and treated at the University of North Carolina. We compared our results to the literature from 1963 to 2014. Results. Mean follow-up was 31 months. Average age at diagnosis was 44.7 years of age. All patients received wide-local excision and adjuvant radiotherapy. No patients recurred during the series. Recurrence-free survival time for the patients was 45, 37, and 3 months, respectively. Conclusions. Our data series confirms that a combined-modality approach with complete surgical resection and adjuvant radiotherapy leads to improved outcomes in MPNSTs of the head and neck. Nonetheless, due to historically poor outcomes, continued research into newer therapies needs to be explored.
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spelling pubmed-42734762014-12-29 Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review Mullins, Brandon T. Hackman, Trevor Case Rep Otolaryngol Case Report Background. Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. Methods. We identified 3 patients presenting with MPNST of the head and neck and treated at the University of North Carolina. We compared our results to the literature from 1963 to 2014. Results. Mean follow-up was 31 months. Average age at diagnosis was 44.7 years of age. All patients received wide-local excision and adjuvant radiotherapy. No patients recurred during the series. Recurrence-free survival time for the patients was 45, 37, and 3 months, respectively. Conclusions. Our data series confirms that a combined-modality approach with complete surgical resection and adjuvant radiotherapy leads to improved outcomes in MPNSTs of the head and neck. Nonetheless, due to historically poor outcomes, continued research into newer therapies needs to be explored. Hindawi Publishing Corporation 2014 2014-12-04 /pmc/articles/PMC4273476/ /pubmed/25548703 http://dx.doi.org/10.1155/2014/368920 Text en Copyright © 2014 B. T. Mullins and T. Hackman. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mullins, Brandon T.
Hackman, Trevor
Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review
title Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review
title_full Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review
title_fullStr Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review
title_full_unstemmed Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review
title_short Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review
title_sort malignant peripheral nerve sheath tumors of the head and neck: a case series and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273476/
https://www.ncbi.nlm.nih.gov/pubmed/25548703
http://dx.doi.org/10.1155/2014/368920
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