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Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report

Introduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Meth...

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Autores principales: Minichino, Amedeo, Bersani, Francesco Saverio, Spagnoli, Francesco, Corrado, Alessandra, De Michele, Francesco, Calò, Wanda Katharina, Primavera, Martina, Yang, Baoran, Bernabei, Laura, Macrì, Francesco, Vergnani, Lucilla, Biondi, Massimo, Delle Chiaie, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273569/
https://www.ncbi.nlm.nih.gov/pubmed/25544804
http://dx.doi.org/10.1155/2014/876521
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author Minichino, Amedeo
Bersani, Francesco Saverio
Spagnoli, Francesco
Corrado, Alessandra
De Michele, Francesco
Calò, Wanda Katharina
Primavera, Martina
Yang, Baoran
Bernabei, Laura
Macrì, Francesco
Vergnani, Lucilla
Biondi, Massimo
Delle Chiaie, Roberto
author_facet Minichino, Amedeo
Bersani, Francesco Saverio
Spagnoli, Francesco
Corrado, Alessandra
De Michele, Francesco
Calò, Wanda Katharina
Primavera, Martina
Yang, Baoran
Bernabei, Laura
Macrì, Francesco
Vergnani, Lucilla
Biondi, Massimo
Delle Chiaie, Roberto
author_sort Minichino, Amedeo
collection PubMed
description Introduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Methods. 25 euthymic outpatients with a diagnosis of BD Type I or II have been enrolled in the study. tDCS montage was as follows: cathode on the right cerebellar cortex and anode over the left dorsolateral prefrontal cortex (DLPFC); the intensity of stimulation was set at 2 mA and delivered for 20 min/die for 3 consecutive weeks. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at baseline and after the tDCS treatment. Results. PSQI total score and all PSQI subdomains, with the exception of “sleep medication,” significantly improved after treatment. Discussion. This is the first study where a positive effect of tDCS on the quality of sleep in euthymic BD patients has been reported. As both prefrontal cortex and cerebellum may play a role in regulating sleep processes, concomitant cathodal (inhibitory) stimulation of cerebellum and anodal (excitatory) stimulation of DLPFC may have the potential to modulate prefrontal-thalamic-cerebellar circuits leading to improvements of sleep quality.
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spelling pubmed-42735692014-12-28 Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report Minichino, Amedeo Bersani, Francesco Saverio Spagnoli, Francesco Corrado, Alessandra De Michele, Francesco Calò, Wanda Katharina Primavera, Martina Yang, Baoran Bernabei, Laura Macrì, Francesco Vergnani, Lucilla Biondi, Massimo Delle Chiaie, Roberto Behav Neurol Clinical Study Introduction. Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. The aim of the study was to improve sleep quality of euthymic BD patients through the administration of prefronto-cerebellar transcranial direct current stimulation (tDCS). Methods. 25 euthymic outpatients with a diagnosis of BD Type I or II have been enrolled in the study. tDCS montage was as follows: cathode on the right cerebellar cortex and anode over the left dorsolateral prefrontal cortex (DLPFC); the intensity of stimulation was set at 2 mA and delivered for 20 min/die for 3 consecutive weeks. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at baseline and after the tDCS treatment. Results. PSQI total score and all PSQI subdomains, with the exception of “sleep medication,” significantly improved after treatment. Discussion. This is the first study where a positive effect of tDCS on the quality of sleep in euthymic BD patients has been reported. As both prefrontal cortex and cerebellum may play a role in regulating sleep processes, concomitant cathodal (inhibitory) stimulation of cerebellum and anodal (excitatory) stimulation of DLPFC may have the potential to modulate prefrontal-thalamic-cerebellar circuits leading to improvements of sleep quality. Hindawi Publishing Corporation 2014 2014-12-07 /pmc/articles/PMC4273569/ /pubmed/25544804 http://dx.doi.org/10.1155/2014/876521 Text en Copyright © 2014 Amedeo Minichino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Minichino, Amedeo
Bersani, Francesco Saverio
Spagnoli, Francesco
Corrado, Alessandra
De Michele, Francesco
Calò, Wanda Katharina
Primavera, Martina
Yang, Baoran
Bernabei, Laura
Macrì, Francesco
Vergnani, Lucilla
Biondi, Massimo
Delle Chiaie, Roberto
Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_full Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_fullStr Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_full_unstemmed Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_short Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report
title_sort prefronto-cerebellar transcranial direct current stimulation improves sleep quality in euthymic bipolar patients: a brief report
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273569/
https://www.ncbi.nlm.nih.gov/pubmed/25544804
http://dx.doi.org/10.1155/2014/876521
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