Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients

Denervated muscles undergo fibrillations due to spontaneous activation of voltage-gated sodium (Na(+)) channels generating action potentials. Fibrillations also occur in patients with amyotrophic lateral sclerosis (ALS). Riluzole, the only approved drug for ALS treatment, blocks voltage-gated Na(+)...

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Detalles Bibliográficos
Autores principales: Deflorio, Cristina, Onesti, Emanuela, Lauro, Clotilde, Tartaglia, Giorgio, Giovannelli, Aldo, Limatola, Cristina, Inghilleri, Maurizio, Grassi, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273590/
https://www.ncbi.nlm.nih.gov/pubmed/25548669
http://dx.doi.org/10.1155/2014/946073

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