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Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura

BACKGROUND: Altered cortical excitability is thought to be part of migraine pathophysiology. Reduced magnetic suppression of perceptual accuracy (MSPA) has been found in episodic migraine with aura and in chronic migraine, and has been interpreted as reduced inhibition of the occipital cortex in the...

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Autores principales: Rauschel, Veronika, Ruscheweyh, Ruth, Eggert, Thomas, Straube, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273691/
https://www.ncbi.nlm.nih.gov/pubmed/25471445
http://dx.doi.org/10.1186/1129-2377-15-83
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author Rauschel, Veronika
Ruscheweyh, Ruth
Eggert, Thomas
Straube, Andreas
author_facet Rauschel, Veronika
Ruscheweyh, Ruth
Eggert, Thomas
Straube, Andreas
author_sort Rauschel, Veronika
collection PubMed
description BACKGROUND: Altered cortical excitability is thought to be part of migraine pathophysiology. Reduced magnetic suppression of perceptual accuracy (MSPA) has been found in episodic migraine with aura and in chronic migraine, and has been interpreted as reduced inhibition of the occipital cortex in these migraine subtypes. Results are less clear for episodic migraine without aura. In the present study we compared MSPA between 24 healthy controls and 22 interictally measured episodic migraine patients without aura. In addition, we investigated test-retest reliability in 33 subjects (24 controls, 9 migraine). FINDINGS: Visual accuracy was assessed by letter recognition and modulated by transcranial magnetic stimulation delivered to the occipital cortex at different intervals to the letter presentation (40, 100 and 190 ms). The results confirm suppression of visual accuracy at the 100 ms interval (p < 0.001), but there were no significant group differences (percentage of correctly recognized letters, control: 36.1 ± 36.2; migraine: 44.0 ± 32.3, p = 0.44). Controls and migraine patients were pooled for assessment of test-retest reliability (n = 33). Levels of suppression at 100 ms were similar at test (percentage of correctly recognized letters: 42.3 ± 32.6) and retest (41.9 ± 33.8, p = 0.90) and test-retest correlations were good (r = 0.82, p < 0.001). CONCLUSIONS: The results demonstrate that occipital cortex inhibition as assessed with MSPA is not reduced in episodic migraine without aura. This suggests a larger role of occipital cortex excitability in episodic migraine with aura and in chronic migraine compared to episodic migraine without aura. Test-retest reliability of MSPA was good.
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spelling pubmed-42736912015-01-15 Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura Rauschel, Veronika Ruscheweyh, Ruth Eggert, Thomas Straube, Andreas J Headache Pain Short Report BACKGROUND: Altered cortical excitability is thought to be part of migraine pathophysiology. Reduced magnetic suppression of perceptual accuracy (MSPA) has been found in episodic migraine with aura and in chronic migraine, and has been interpreted as reduced inhibition of the occipital cortex in these migraine subtypes. Results are less clear for episodic migraine without aura. In the present study we compared MSPA between 24 healthy controls and 22 interictally measured episodic migraine patients without aura. In addition, we investigated test-retest reliability in 33 subjects (24 controls, 9 migraine). FINDINGS: Visual accuracy was assessed by letter recognition and modulated by transcranial magnetic stimulation delivered to the occipital cortex at different intervals to the letter presentation (40, 100 and 190 ms). The results confirm suppression of visual accuracy at the 100 ms interval (p < 0.001), but there were no significant group differences (percentage of correctly recognized letters, control: 36.1 ± 36.2; migraine: 44.0 ± 32.3, p = 0.44). Controls and migraine patients were pooled for assessment of test-retest reliability (n = 33). Levels of suppression at 100 ms were similar at test (percentage of correctly recognized letters: 42.3 ± 32.6) and retest (41.9 ± 33.8, p = 0.90) and test-retest correlations were good (r = 0.82, p < 0.001). CONCLUSIONS: The results demonstrate that occipital cortex inhibition as assessed with MSPA is not reduced in episodic migraine without aura. This suggests a larger role of occipital cortex excitability in episodic migraine with aura and in chronic migraine compared to episodic migraine without aura. Test-retest reliability of MSPA was good. Springer 2014-12-03 /pmc/articles/PMC4273691/ /pubmed/25471445 http://dx.doi.org/10.1186/1129-2377-15-83 Text en Copyright © 2014 Rauschel et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Short Report
Rauschel, Veronika
Ruscheweyh, Ruth
Eggert, Thomas
Straube, Andreas
Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura
title Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura
title_full Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura
title_fullStr Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura
title_full_unstemmed Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura
title_short Magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura
title_sort magnetic suppression of perceptual accuracy is not reduced in episodic migraine without aura
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273691/
https://www.ncbi.nlm.nih.gov/pubmed/25471445
http://dx.doi.org/10.1186/1129-2377-15-83
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