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Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia
BACKGROUND: Viruses are increasingly recognized as major causes of community-acquired pneumonia (CAP). Few studies have investigated the clinical predictors of viral pneumonia, and the results have been inconsistent. In this study, the clinical predictors of viral pneumonia were investigated in term...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273967/ https://www.ncbi.nlm.nih.gov/pubmed/25531901 http://dx.doi.org/10.1371/journal.pone.0114710 |
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author | Kim, Ji Eun Kim, Uh Jin Kim, Hee Kyung Cho, Soo Kyung An, Joon Hwan Kang, Seung-Ji Park, Kyung-Hwa Jung, Sook-In Jang, Hee-Chang |
author_facet | Kim, Ji Eun Kim, Uh Jin Kim, Hee Kyung Cho, Soo Kyung An, Joon Hwan Kang, Seung-Ji Park, Kyung-Hwa Jung, Sook-In Jang, Hee-Chang |
author_sort | Kim, Ji Eun |
collection | PubMed |
description | BACKGROUND: Viruses are increasingly recognized as major causes of community-acquired pneumonia (CAP). Few studies have investigated the clinical predictors of viral pneumonia, and the results have been inconsistent. In this study, the clinical predictors of viral pneumonia were investigated in terms of their utility as indicators for viral pneumonia in patients with CAP. METHODS: Adult patients (≥18 years old) with CAP, tested by polymerase chain reaction (PCR) for respiratory virus, at two teaching hospitals between October 2010 and May 2013, were identified retrospectively. Demographic and clinical data were collected by reviewing the hospital electronic medical records. RESULTS: During the study period, 456 patients with CAP were identified who met the definition, and 327 (72%) patients were tested using the respiratory virus PCR detection test. Viral pneumonia (n = 60) was associated with rhinorrhea, a higher lymphocyte fraction in the white blood cells, lower serum creatinine and ground-glass opacity (GGO) in radiology results, compared to non-viral pneumonia (n = 250) (p<0.05, each). In a multivariate analysis, rhinorrhea (Odd ratio (OR) 3.52; 95% Confidence interval (CI), 1.58–7.87) and GGO (OR 4.68; 95% CI, 2.48–8.89) were revealed as independent risk factors for viral pneumonia in patients with CAP. The sensitivity, specificity, positive- and negative-predictive values (PPV and NPV) of rhinorrhea were 22, 91, 36 and 83%: the sensitivity, specificity, PPV and NPV of GGO were and 43, 84, 40 and 86%, respectively. CONCLUSION: Symptom of rhinorrhea and GGO predicted viral pneumonia in patients with CAP. The high specificity of rhinorrhea and GGO suggested that these could be useful indicators for empirical antiviral therapy. |
format | Online Article Text |
id | pubmed-4273967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42739672014-12-31 Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia Kim, Ji Eun Kim, Uh Jin Kim, Hee Kyung Cho, Soo Kyung An, Joon Hwan Kang, Seung-Ji Park, Kyung-Hwa Jung, Sook-In Jang, Hee-Chang PLoS One Research Article BACKGROUND: Viruses are increasingly recognized as major causes of community-acquired pneumonia (CAP). Few studies have investigated the clinical predictors of viral pneumonia, and the results have been inconsistent. In this study, the clinical predictors of viral pneumonia were investigated in terms of their utility as indicators for viral pneumonia in patients with CAP. METHODS: Adult patients (≥18 years old) with CAP, tested by polymerase chain reaction (PCR) for respiratory virus, at two teaching hospitals between October 2010 and May 2013, were identified retrospectively. Demographic and clinical data were collected by reviewing the hospital electronic medical records. RESULTS: During the study period, 456 patients with CAP were identified who met the definition, and 327 (72%) patients were tested using the respiratory virus PCR detection test. Viral pneumonia (n = 60) was associated with rhinorrhea, a higher lymphocyte fraction in the white blood cells, lower serum creatinine and ground-glass opacity (GGO) in radiology results, compared to non-viral pneumonia (n = 250) (p<0.05, each). In a multivariate analysis, rhinorrhea (Odd ratio (OR) 3.52; 95% Confidence interval (CI), 1.58–7.87) and GGO (OR 4.68; 95% CI, 2.48–8.89) were revealed as independent risk factors for viral pneumonia in patients with CAP. The sensitivity, specificity, positive- and negative-predictive values (PPV and NPV) of rhinorrhea were 22, 91, 36 and 83%: the sensitivity, specificity, PPV and NPV of GGO were and 43, 84, 40 and 86%, respectively. CONCLUSION: Symptom of rhinorrhea and GGO predicted viral pneumonia in patients with CAP. The high specificity of rhinorrhea and GGO suggested that these could be useful indicators for empirical antiviral therapy. Public Library of Science 2014-12-22 /pmc/articles/PMC4273967/ /pubmed/25531901 http://dx.doi.org/10.1371/journal.pone.0114710 Text en © 2014 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kim, Ji Eun Kim, Uh Jin Kim, Hee Kyung Cho, Soo Kyung An, Joon Hwan Kang, Seung-Ji Park, Kyung-Hwa Jung, Sook-In Jang, Hee-Chang Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia |
title | Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia |
title_full | Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia |
title_fullStr | Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia |
title_full_unstemmed | Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia |
title_short | Predictors of Viral Pneumonia in Patients with Community-Acquired Pneumonia |
title_sort | predictors of viral pneumonia in patients with community-acquired pneumonia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273967/ https://www.ncbi.nlm.nih.gov/pubmed/25531901 http://dx.doi.org/10.1371/journal.pone.0114710 |
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