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PARP Inhibition Restores Extrinsic Apoptotic Sensitivity in Glioblastoma

BACKGROUND: Resistance to apoptosis is a paramount issue in the treatment of Glioblastoma (GBM). We show that targeting PARP by the small molecule inhibitors, Olaparib (AZD-2281) or PJ34, reduces proliferation and lowers the apoptotic threshold of GBM cells in vitro and in vivo. METHODS: The sensiti...

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Detalles Bibliográficos
Autores principales:	Karpel-Massler, Georg, Pareja, Fresia, Aimé, Pascaline, Shu, Chang, Chau, Lily, Westhoff, Mike-Andrew, Halatsch, Marc-Eric, Crary, John F., Canoll, Peter, Siegelin, Markus D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273972/ https://www.ncbi.nlm.nih.gov/pubmed/25531448 http://dx.doi.org/10.1371/journal.pone.0114583

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