Cargando…

Identification of Small Molecules That Protect Pancreatic β Cells against Endoplasmic Reticulum Stress-Induced Cell Death

[Image: see text] Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes. Here, we developed a novel β cell-based high-throughput screening assay to identify small molecules that protect β cells against ER stress-in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tran, Kim, Li, Yu, Duan, Hongliang, Arora, Daleep, Lim, Hui-Ying, Wang, Weidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273981/ https://www.ncbi.nlm.nih.gov/pubmed/25279668 http://dx.doi.org/10.1021/cb500740d

Ejemplares similares

Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells
por: Quan, Wenying, et al.
Publicado: (2012)

Endoplasmic Reticulum Redox State Is Not Perturbed by Pharmacological or Pathological Endoplasmic Reticulum Stress in Live Pancreatic β-Cells
por: Schuiki, Irmgard, et al.
Publicado: (2012)

Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells
por: Zhu, Yunxia, et al.
Publicado: (2019)

Endoplasmic reticulum involvement in yeast cell death
por: Austriaco, O. P., Nicanor
Publicado: (2012)

The endoplasmic reticulum in plant immunity and cell death
por: Eichmann, Ruth, et al.
Publicado: (2012)

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
por: Åkerfeldt, Mia C., et al.
Publicado: (2008)

Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
por: Cao, Zhao-Hui, et al.
Publicado: (2020)

The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export
por: Lu, Lei, et al.
Publicado: (2013)

Uncoupling Proteostasis and Development in Vitro with a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK
por: Harding, Heather P., et al.
Publicado: (2012)

Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death
por: Merighi, Adalberto, et al.
Publicado: (2022)

FENESTRAE IN THE ROUGH ENDOPLASMIC RETICULUM OF THE EXOCRINE PANCREATIC CELLS
por: Orci, Lelio, et al.
Publicado: (1972)

The deubiquitinase USP10 protects pancreatic cancer cells from endoplasmic reticulum stress
por: Bhattacharya, Udayan, et al.
Publicado: (2022)

Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress
por: Zhang, Rui, et al.
Publicado: (2011)

Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells
por: Hong, Seok-Woo, et al.
Publicado: (2018)

Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors
por: Fu, Xiaojing, et al.
Publicado: (2021)

A Pipeline for Natural Small Molecule Inhibitors of Endoplasmic Reticulum Stress
por: Correia da Silva, Daniela, et al.
Publicado: (2022)

Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection
por: Xu, Jiancheng, et al.
Publicado: (2009)

Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death
por: Shibusawa, Ryo, et al.
Publicado: (2019)

Endoplasmic reticulum stress-mediated cell death in liver injury
por: Zhang, Jian, et al.
Publicado: (2022)

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
por: Cnop, Miriam, et al.
Publicado: (2017)

The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury
por: Kong, Fei-Juan, et al.
Publicado: (2017)

Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells
por: Saegusa, Keiko, et al.
Publicado: (2022)

Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
por: Fauzi, Muhammad, et al.
Publicado: (2022)

Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress
por: Kim, Bomi, et al.
Publicado: (2017)

The Potential of Small Molecules to Modulate the Mitochondria–Endoplasmic Reticulum Interplay in Alzheimer’s Disease
por: Dentoni, Giacomo, et al.
Publicado: (2022)

Benzodiazepinone Derivatives Protect against Endoplasmic Reticulum Stress-Mediated Cell Death in Human Neuronal Cell Lines
por: Zou, Haixia, et al.
Publicado: (2014)

Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells
por: Yu, Kyeong-Nam, et al.
Publicado: (2015)

Receptor interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death
por: Feng, Xudong, et al.
Publicado: (2014)

The Protective Role of Calbindin-D(9k) on Endoplasmic Reticulum Stress-Induced Beta Cell Death
por: Ahn, Changhwan, et al.
Publicado: (2019)

Protective Effect of Hawthorn Fruit Extract against High Fructose-Induced Oxidative Stress and Endoplasmic Reticulum Stress in Pancreatic β-Cells
por: Lien, Hsiu-Man, et al.
Publicado: (2023)

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
por: Hitomi, Junichi, et al.
Publicado: (2004)

C/EBP-β Regulates Endoplasmic Reticulum Stress–Triggered Cell Death in Mouse and Human Models
por: Meir, Ofir, et al.
Publicado: (2010)

Abortive Autophagy Induces Endoplasmic Reticulum Stress and Cell Death in Cancer Cells
por: Claerhout, Sofie, et al.
Publicado: (2012)

Targeting BIP to induce Endoplasmic Reticulum stress and cancer cell death
por: Cerezo, Michaël, et al.
Publicado: (2016)

The Role of Endoplasmic Reticulum Stress in Cell Injury Induced by Methimazole on Pancreatic Cells
por: Yazıcı, Özge, et al.
Publicado: (2023)

Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells
Publicado: (1989)

Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
por: Moon, Seoil, et al.
Publicado: (2022)

PARM-1 Is an Endoplasmic Reticulum Molecule Involved in Endoplasmic Reticulum Stress-Induced Apoptosis in Rat Cardiac Myocytes
por: Isodono, Koji, et al.
Publicado: (2010)

The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis
por: Yu, Cong, et al.
Publicado: (2015)

Correction: C/EBP-β Regulates Endoplasmic Reticulum Stress–Triggered Cell Death in Mouse and Human Models
por: Meir, Ofir, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_sr2ojabft8daelk0g8o7bgn0qr