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The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile

Extracellular Tat (eTat) plays an important role in HIV-1 pathogenesis. The presence of anti-Tat antibodies is negatively correlated with disease progression, hence making Tat a potential vaccine candidate. The cytotoxicity and moderate immunogenicity of Tat however remain impediments for developing...

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Detalles Bibliográficos
Autores principales:	Kashi, Venkatesh P., Jacob, Rajesh A., Shamanna, Raghavendra A., Menon, Malini, Balasiddaiah, Anangi, Varghese, Rebu K., Bachu, Mahesh, Ranga, Udaykumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273983/ https://www.ncbi.nlm.nih.gov/pubmed/25531437 http://dx.doi.org/10.1371/journal.pone.0114155

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