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Fluorinated Aromatic Amino Acids Are Sensitive (19)F NMR Probes for Bromodomain-Ligand Interactions

[Image: see text] We describe a (19)F NMR method for detecting bromodomain–ligand interactions using fluorine-labeled aromatic amino acids due to the conservation of aromatic residues in the bromodomain binding site. We test the sensitivity, accuracy, and speed of this method with small molecule lig...

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Detalles Bibliográficos
Autores principales:	Mishra, Neeraj K., Urick, Andrew K., Ember, Stuart W. J., Schönbrunn, Ernst, Pomerantz, William C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273984/ https://www.ncbi.nlm.nih.gov/pubmed/25290579 http://dx.doi.org/10.1021/cb5007344

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