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Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function

Type 2 diabetes is characterised by an age-related decline in insulin secretion. We previously identified a 50% age-related decline in mitochondrial DNA (mtDNA) copy number in isolated human islets. The purpose of this study was to mimic this degree of mtDNA depletion in MIN6 cells to determine whet...

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Detalles Bibliográficos
Autores principales:	Nile, Donna L., Brown, Audrey E., Kumaheri, Meutia A., Blair, Helen R., Heggie, Alison, Miwa, Satomi, Cree, Lynsey M., Payne, Brendan, Chinnery, Patrick F., Brown, Louise, Gunn, David A., Walker, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274008/ https://www.ncbi.nlm.nih.gov/pubmed/25532126 http://dx.doi.org/10.1371/journal.pone.0115433

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