CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization

CGI-58/ABHD5 coactivates adipose triglyceride lipase (ATGL). In adipocytes, CGI-58 binds to perilipin 1A on lipid droplets under basal conditions, preventing interaction with ATGL. Upon activation of protein kinase A (PKA), perilipin 1A is phosphorylated and CGI-58 rapidly disperses into the cytopla...

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Detalles Bibliográficos
Autores principales: Sahu-Osen, Anita, Montero-Moran, Gabriela, Schittmayer, Matthias, Fritz, Katarina, Dinh, Anna, Chang, Yu-Fang, McMahon, Derek, Boeszoermenyi, Andras, Cornaciu, Irina, Russell, Deanna, Oberer, Monika, Carman, George M., Birner-Gruenberger, Ruth, Brasaemle, Dawn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274058/
https://www.ncbi.nlm.nih.gov/pubmed/25421061
http://dx.doi.org/10.1194/jlr.M055004

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