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Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder

Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary m...

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Autores principales: Chen, Jian-jun, Huang, Hua, Zhao, Li-bo, Zhou, De-zhi, Yang, Yong-tao, Zheng, Peng, Yang, De-yu, He, Peng, Zhou, Jing-jing, Fang, Liang, Xie, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274077/
https://www.ncbi.nlm.nih.gov/pubmed/25531985
http://dx.doi.org/10.1371/journal.pone.0115221
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author Chen, Jian-jun
Huang, Hua
Zhao, Li-bo
Zhou, De-zhi
Yang, Yong-tao
Zheng, Peng
Yang, De-yu
He, Peng
Zhou, Jing-jing
Fang, Liang
Xie, Peng
author_facet Chen, Jian-jun
Huang, Hua
Zhao, Li-bo
Zhou, De-zhi
Yang, Yong-tao
Zheng, Peng
Yang, De-yu
He, Peng
Zhou, Jing-jing
Fang, Liang
Xie, Peng
author_sort Chen, Jian-jun
collection PubMed
description Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers for diagnosing male and female BD patients. A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, and N-methylnicotinamide) effectively discriminated between male BD and healthy controls (HC) subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.942. A female-specific biomarkers panel consisting of four metabolites (α-hydroxybutyrate, oxalacetate, acetone, and N-methylnicotinamide) effectively discriminated between female BD and HC subjects, achieving an AUC of 0.909. The male-specific biomarker panel displayed low discriminatory power in the female group, and the female-specific biomarker panel displayed low discriminatory power in the male group. Moreover, several other metabolites showed different trends between male and female BD subjects. These findings suggest that male and female BD patients have distinct biomarker fingerprints and that these two sex-specific biomarker panels may serve as effective diagnostic tools in distinguishing male and female BD patients from their healthy counterparts. Our work may provide a window into the mechanisms underlying the pathoetiology of BD in both men and women.
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spelling pubmed-42740772014-12-31 Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder Chen, Jian-jun Huang, Hua Zhao, Li-bo Zhou, De-zhi Yang, Yong-tao Zheng, Peng Yang, De-yu He, Peng Zhou, Jing-jing Fang, Liang Xie, Peng PLoS One Research Article Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers for diagnosing male and female BD patients. A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, and N-methylnicotinamide) effectively discriminated between male BD and healthy controls (HC) subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.942. A female-specific biomarkers panel consisting of four metabolites (α-hydroxybutyrate, oxalacetate, acetone, and N-methylnicotinamide) effectively discriminated between female BD and HC subjects, achieving an AUC of 0.909. The male-specific biomarker panel displayed low discriminatory power in the female group, and the female-specific biomarker panel displayed low discriminatory power in the male group. Moreover, several other metabolites showed different trends between male and female BD subjects. These findings suggest that male and female BD patients have distinct biomarker fingerprints and that these two sex-specific biomarker panels may serve as effective diagnostic tools in distinguishing male and female BD patients from their healthy counterparts. Our work may provide a window into the mechanisms underlying the pathoetiology of BD in both men and women. Public Library of Science 2014-12-22 /pmc/articles/PMC4274077/ /pubmed/25531985 http://dx.doi.org/10.1371/journal.pone.0115221 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chen, Jian-jun
Huang, Hua
Zhao, Li-bo
Zhou, De-zhi
Yang, Yong-tao
Zheng, Peng
Yang, De-yu
He, Peng
Zhou, Jing-jing
Fang, Liang
Xie, Peng
Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder
title Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder
title_full Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder
title_fullStr Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder
title_full_unstemmed Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder
title_short Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder
title_sort sex-specific urinary biomarkers for diagnosing bipolar disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274077/
https://www.ncbi.nlm.nih.gov/pubmed/25531985
http://dx.doi.org/10.1371/journal.pone.0115221
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