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Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder
Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary m...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274077/ https://www.ncbi.nlm.nih.gov/pubmed/25531985 http://dx.doi.org/10.1371/journal.pone.0115221 |
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author | Chen, Jian-jun Huang, Hua Zhao, Li-bo Zhou, De-zhi Yang, Yong-tao Zheng, Peng Yang, De-yu He, Peng Zhou, Jing-jing Fang, Liang Xie, Peng |
author_facet | Chen, Jian-jun Huang, Hua Zhao, Li-bo Zhou, De-zhi Yang, Yong-tao Zheng, Peng Yang, De-yu He, Peng Zhou, Jing-jing Fang, Liang Xie, Peng |
author_sort | Chen, Jian-jun |
collection | PubMed |
description | Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers for diagnosing male and female BD patients. A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, and N-methylnicotinamide) effectively discriminated between male BD and healthy controls (HC) subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.942. A female-specific biomarkers panel consisting of four metabolites (α-hydroxybutyrate, oxalacetate, acetone, and N-methylnicotinamide) effectively discriminated between female BD and HC subjects, achieving an AUC of 0.909. The male-specific biomarker panel displayed low discriminatory power in the female group, and the female-specific biomarker panel displayed low discriminatory power in the male group. Moreover, several other metabolites showed different trends between male and female BD subjects. These findings suggest that male and female BD patients have distinct biomarker fingerprints and that these two sex-specific biomarker panels may serve as effective diagnostic tools in distinguishing male and female BD patients from their healthy counterparts. Our work may provide a window into the mechanisms underlying the pathoetiology of BD in both men and women. |
format | Online Article Text |
id | pubmed-4274077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42740772014-12-31 Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder Chen, Jian-jun Huang, Hua Zhao, Li-bo Zhou, De-zhi Yang, Yong-tao Zheng, Peng Yang, De-yu He, Peng Zhou, Jing-jing Fang, Liang Xie, Peng PLoS One Research Article Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers for diagnosing male and female BD patients. A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, and N-methylnicotinamide) effectively discriminated between male BD and healthy controls (HC) subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.942. A female-specific biomarkers panel consisting of four metabolites (α-hydroxybutyrate, oxalacetate, acetone, and N-methylnicotinamide) effectively discriminated between female BD and HC subjects, achieving an AUC of 0.909. The male-specific biomarker panel displayed low discriminatory power in the female group, and the female-specific biomarker panel displayed low discriminatory power in the male group. Moreover, several other metabolites showed different trends between male and female BD subjects. These findings suggest that male and female BD patients have distinct biomarker fingerprints and that these two sex-specific biomarker panels may serve as effective diagnostic tools in distinguishing male and female BD patients from their healthy counterparts. Our work may provide a window into the mechanisms underlying the pathoetiology of BD in both men and women. Public Library of Science 2014-12-22 /pmc/articles/PMC4274077/ /pubmed/25531985 http://dx.doi.org/10.1371/journal.pone.0115221 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chen, Jian-jun Huang, Hua Zhao, Li-bo Zhou, De-zhi Yang, Yong-tao Zheng, Peng Yang, De-yu He, Peng Zhou, Jing-jing Fang, Liang Xie, Peng Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder |
title | Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder |
title_full | Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder |
title_fullStr | Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder |
title_full_unstemmed | Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder |
title_short | Sex-Specific Urinary Biomarkers for Diagnosing Bipolar Disorder |
title_sort | sex-specific urinary biomarkers for diagnosing bipolar disorder |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274077/ https://www.ncbi.nlm.nih.gov/pubmed/25531985 http://dx.doi.org/10.1371/journal.pone.0115221 |
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