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Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders
BACKGROUND: Renal involvement in Schistosoma mansoni infection is not well studied. The aim of this study is to investigate the occurrence of renal abnormalities in patients with hepatosplenic schistosomiasis (HSS), especially renal tubular disorders. METHODS: This is a cross-sectional study with 20...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274079/ https://www.ncbi.nlm.nih.gov/pubmed/25531759 http://dx.doi.org/10.1371/journal.pone.0115197 |
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author | Duarte, Daniella Bezerra Vanderlei, Lucas Alexandre de Azevêdo Bispo, Raianne Kívia Pinheiro, Maria Eliete da Silva Junior, Geraldo Bezerra Martins, Alice Maria Costa Meneses, Gdayllon Cavalcante De Francesco Daher, Elizabeth |
author_facet | Duarte, Daniella Bezerra Vanderlei, Lucas Alexandre de Azevêdo Bispo, Raianne Kívia Pinheiro, Maria Eliete da Silva Junior, Geraldo Bezerra Martins, Alice Maria Costa Meneses, Gdayllon Cavalcante De Francesco Daher, Elizabeth |
author_sort | Duarte, Daniella Bezerra |
collection | PubMed |
description | BACKGROUND: Renal involvement in Schistosoma mansoni infection is not well studied. The aim of this study is to investigate the occurrence of renal abnormalities in patients with hepatosplenic schistosomiasis (HSS), especially renal tubular disorders. METHODS: This is a cross-sectional study with 20 consecutive patients with HSS followed in a medical center in Maceió, Alagoas, Brazil. Urinary acidification and concentration tests were performed using calcium chloride (CaCl(2)) after a 12-h period of water and food deprivation. The biomarker monocyte chemoattractant protein 1 (MCP-1) was quantified in urine. Fractional excretion of sodium (FE(Na+)), transtubular potassium gradient (TTKG) and solute-free water reabsorption (TcH(2)O) were calculated. The HSS group was compared to a group of 17 healthy volunteers. RESULTS: Patients' mean age and gender were similar to controls. Urinary acidification deficit was found in 45% of HSS patients. Urinary osmolality was significantly lower in HSS patients (588±112 vs. 764±165 mOsm/kg, p = 0,001) after a 12-h period of water deprivation. TcH(2)O was lower in HSS patients (0.72±0.5 vs. 1.1±0.3, p = 0.04). Urinary concentration deficit was found in 85% of HSS patients. The values of MCP-1 were higher in HSS group than in control group (122±134 vs. 40±28 pg/mg-Cr, p = 0.01) and positively correlated with the values of microalbuminuria and proteinuria. CONCLUSIONS: HSS is associated with important kidney dysfunction. The main abnormalities found were urinary concentrating ability and incomplete distal acidification defect, demonstrating the occurrence of tubular dysfunction. There was also an increase in urinary MCP-1, which appears to be a more sensitive marker of renal damage than urinary albumin excretion rate. |
format | Online Article Text |
id | pubmed-4274079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42740792014-12-31 Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders Duarte, Daniella Bezerra Vanderlei, Lucas Alexandre de Azevêdo Bispo, Raianne Kívia Pinheiro, Maria Eliete da Silva Junior, Geraldo Bezerra Martins, Alice Maria Costa Meneses, Gdayllon Cavalcante De Francesco Daher, Elizabeth PLoS One Research Article BACKGROUND: Renal involvement in Schistosoma mansoni infection is not well studied. The aim of this study is to investigate the occurrence of renal abnormalities in patients with hepatosplenic schistosomiasis (HSS), especially renal tubular disorders. METHODS: This is a cross-sectional study with 20 consecutive patients with HSS followed in a medical center in Maceió, Alagoas, Brazil. Urinary acidification and concentration tests were performed using calcium chloride (CaCl(2)) after a 12-h period of water and food deprivation. The biomarker monocyte chemoattractant protein 1 (MCP-1) was quantified in urine. Fractional excretion of sodium (FE(Na+)), transtubular potassium gradient (TTKG) and solute-free water reabsorption (TcH(2)O) were calculated. The HSS group was compared to a group of 17 healthy volunteers. RESULTS: Patients' mean age and gender were similar to controls. Urinary acidification deficit was found in 45% of HSS patients. Urinary osmolality was significantly lower in HSS patients (588±112 vs. 764±165 mOsm/kg, p = 0,001) after a 12-h period of water deprivation. TcH(2)O was lower in HSS patients (0.72±0.5 vs. 1.1±0.3, p = 0.04). Urinary concentration deficit was found in 85% of HSS patients. The values of MCP-1 were higher in HSS group than in control group (122±134 vs. 40±28 pg/mg-Cr, p = 0.01) and positively correlated with the values of microalbuminuria and proteinuria. CONCLUSIONS: HSS is associated with important kidney dysfunction. The main abnormalities found were urinary concentrating ability and incomplete distal acidification defect, demonstrating the occurrence of tubular dysfunction. There was also an increase in urinary MCP-1, which appears to be a more sensitive marker of renal damage than urinary albumin excretion rate. Public Library of Science 2014-12-22 /pmc/articles/PMC4274079/ /pubmed/25531759 http://dx.doi.org/10.1371/journal.pone.0115197 Text en © 2014 Duarte et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Duarte, Daniella Bezerra Vanderlei, Lucas Alexandre de Azevêdo Bispo, Raianne Kívia Pinheiro, Maria Eliete da Silva Junior, Geraldo Bezerra Martins, Alice Maria Costa Meneses, Gdayllon Cavalcante De Francesco Daher, Elizabeth Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders |
title | Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders |
title_full | Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders |
title_fullStr | Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders |
title_full_unstemmed | Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders |
title_short | Renal Function in Hepatosplenic Schistosomiasis – An Assessment of Renal Tubular Disorders |
title_sort | renal function in hepatosplenic schistosomiasis – an assessment of renal tubular disorders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274079/ https://www.ncbi.nlm.nih.gov/pubmed/25531759 http://dx.doi.org/10.1371/journal.pone.0115197 |
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