Prostate-Specific Antigen and Perfluoroalkyl Acids in the C8 Health Study Population

PURPOSE: To inform questions raised by inconsistent findings regarding an association between perfluoroalkyl acids (PFAAs) and prostate cancer by assessing the relationship of PFAAs in human serum to prostate-specific antigen (PSA). MATERIALS AND METHODS: Using 2005 to 2006 survey data from a large...

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Detalles Bibliográficos
Autores principales: Ducatman, Alan, Zhang, Jianjun, Fan, Hongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Occupational and Environmental Medicine 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274321/
https://www.ncbi.nlm.nih.gov/pubmed/25563548
http://dx.doi.org/10.1097/JOM.0000000000000319
Descripción
Sumario:PURPOSE: To inform questions raised by inconsistent findings regarding an association between perfluoroalkyl acids (PFAAs) and prostate cancer by assessing the relationship of PFAAs in human serum to prostate-specific antigen (PSA). MATERIALS AND METHODS: Using 2005 to 2006 survey data from a large survey population, we compared serum PFAA concentrations in adult males with PSA concentrations adjusted for risk factors including age, body mass index, smoking status, and socioeconomic status. RESULTS: Perfluoroalkyl acids are not consistently associated with PSA concentration in general, or with PSA more than 4.0. DISCUSSION: These findings do not provide evidence that PFAA exposure is associated with PSA.

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