Prostate-Specific Antigen and Perfluoroalkyl Acids in the C8 Health Study Population

PURPOSE: To inform questions raised by inconsistent findings regarding an association between perfluoroalkyl acids (PFAAs) and prostate cancer by assessing the relationship of PFAAs in human serum to prostate-specific antigen (PSA). MATERIALS AND METHODS: Using 2005 to 2006 survey data from a large survey population, we compared serum PFAA concentrations in adult males with PSA concentrations adjusted for risk factors including age, body mass index, smoking status, and socioeconomic status. RESULTS: Perfluoroalkyl acids are not consistently associated with PSA concentration in general, or with PSA more than 4.0. DISCUSSION: These findings do not provide evidence that PFAA exposure is associated with PSA.