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A conditioned visual orientation requires the ellipsoid body in Drosophila

Orientation, the spatial organization of animal behavior, is an essential faculty of animals. Bacteria and lower animals such as insects exhibit taxis, innate orientation behavior, directly toward or away from a directional cue. Organisms can also orient themselves at a specific angle relative to th...

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Autores principales: Guo, Chao, Du, Yifei, Yuan, Deliang, Li, Meixia, Gong, Haiyun, Gong, Zhefeng, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274327/
https://www.ncbi.nlm.nih.gov/pubmed/25512578
http://dx.doi.org/10.1101/lm.036863.114
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author Guo, Chao
Du, Yifei
Yuan, Deliang
Li, Meixia
Gong, Haiyun
Gong, Zhefeng
Liu, Li
author_facet Guo, Chao
Du, Yifei
Yuan, Deliang
Li, Meixia
Gong, Haiyun
Gong, Zhefeng
Liu, Li
author_sort Guo, Chao
collection PubMed
description Orientation, the spatial organization of animal behavior, is an essential faculty of animals. Bacteria and lower animals such as insects exhibit taxis, innate orientation behavior, directly toward or away from a directional cue. Organisms can also orient themselves at a specific angle relative to the cues. In this study, using Drosophila as a model system, we established a visual orientation conditioning paradigm based on a flight simulator in which a stationary flying fly could control the rotation of a visual object. By coupling aversive heat shocks to a fly's orientation toward one side of the visual object, we found that the fly could be conditioned to orientate toward the left or right side of the frontal visual object and retain this conditioned visual orientation. The lower and upper visual fields have different roles in conditioned visual orientation. Transfer experiments showed that conditioned visual orientation could generalize between visual targets of different sizes, compactness, or vertical positions, but not of contour orientation. Rut—Type I adenylyl cyclase and Dnc—phosphodiesterase were dispensable for visual orientation conditioning. Normal activity and scb signaling in R3/R4d neurons of the ellipsoid body were required for visual orientation conditioning. Our studies established a visual orientation conditioning paradigm and examined the behavioral properties and neural circuitry of visual orientation, an important component of the insect's spatial navigation.
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spelling pubmed-42743272016-01-01 A conditioned visual orientation requires the ellipsoid body in Drosophila Guo, Chao Du, Yifei Yuan, Deliang Li, Meixia Gong, Haiyun Gong, Zhefeng Liu, Li Learn Mem Research Orientation, the spatial organization of animal behavior, is an essential faculty of animals. Bacteria and lower animals such as insects exhibit taxis, innate orientation behavior, directly toward or away from a directional cue. Organisms can also orient themselves at a specific angle relative to the cues. In this study, using Drosophila as a model system, we established a visual orientation conditioning paradigm based on a flight simulator in which a stationary flying fly could control the rotation of a visual object. By coupling aversive heat shocks to a fly's orientation toward one side of the visual object, we found that the fly could be conditioned to orientate toward the left or right side of the frontal visual object and retain this conditioned visual orientation. The lower and upper visual fields have different roles in conditioned visual orientation. Transfer experiments showed that conditioned visual orientation could generalize between visual targets of different sizes, compactness, or vertical positions, but not of contour orientation. Rut—Type I adenylyl cyclase and Dnc—phosphodiesterase were dispensable for visual orientation conditioning. Normal activity and scb signaling in R3/R4d neurons of the ellipsoid body were required for visual orientation conditioning. Our studies established a visual orientation conditioning paradigm and examined the behavioral properties and neural circuitry of visual orientation, an important component of the insect's spatial navigation. Cold Spring Harbor Laboratory Press 2015-01 /pmc/articles/PMC4274327/ /pubmed/25512578 http://dx.doi.org/10.1101/lm.036863.114 Text en © 2014 Guo et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Guo, Chao
Du, Yifei
Yuan, Deliang
Li, Meixia
Gong, Haiyun
Gong, Zhefeng
Liu, Li
A conditioned visual orientation requires the ellipsoid body in Drosophila
title A conditioned visual orientation requires the ellipsoid body in Drosophila
title_full A conditioned visual orientation requires the ellipsoid body in Drosophila
title_fullStr A conditioned visual orientation requires the ellipsoid body in Drosophila
title_full_unstemmed A conditioned visual orientation requires the ellipsoid body in Drosophila
title_short A conditioned visual orientation requires the ellipsoid body in Drosophila
title_sort conditioned visual orientation requires the ellipsoid body in drosophila
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274327/
https://www.ncbi.nlm.nih.gov/pubmed/25512578
http://dx.doi.org/10.1101/lm.036863.114
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