Clozapine-Induced Liver Injury and Pleural Effusion

Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion ass...

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Autores principales: Kane, Joseph P.M., O’Neill, Francis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274456/
https://www.ncbi.nlm.nih.gov/pubmed/25553232
http://dx.doi.org/10.4081/mi.2014.5403
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author Kane, Joseph P.M.
O’Neill, Francis A.
author_facet Kane, Joseph P.M.
O’Neill, Francis A.
author_sort Kane, Joseph P.M.
collection PubMed
description Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion associated with clozapine, resolving after cessation of the agent. The case supports existing literature in advocating a high index of suspicion, particularly in the 4-5 weeks following clozapine initiation, when considering nonspecific clinical symptoms and signs.
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spelling pubmed-42744562014-12-31 Clozapine-Induced Liver Injury and Pleural Effusion Kane, Joseph P.M. O’Neill, Francis A. Ment Illn Case Report Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion associated with clozapine, resolving after cessation of the agent. The case supports existing literature in advocating a high index of suspicion, particularly in the 4-5 weeks following clozapine initiation, when considering nonspecific clinical symptoms and signs. PAGEPress Publications, Pavia, Italy 2014-09-08 /pmc/articles/PMC4274456/ /pubmed/25553232 http://dx.doi.org/10.4081/mi.2014.5403 Text en ©Copyright J.P.M. Kane and F.A. O’Neill http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kane, Joseph P.M.
O’Neill, Francis A.
Clozapine-Induced Liver Injury and Pleural Effusion
title Clozapine-Induced Liver Injury and Pleural Effusion
title_full Clozapine-Induced Liver Injury and Pleural Effusion
title_fullStr Clozapine-Induced Liver Injury and Pleural Effusion
title_full_unstemmed Clozapine-Induced Liver Injury and Pleural Effusion
title_short Clozapine-Induced Liver Injury and Pleural Effusion
title_sort clozapine-induced liver injury and pleural effusion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274456/
https://www.ncbi.nlm.nih.gov/pubmed/25553232
http://dx.doi.org/10.4081/mi.2014.5403
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