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Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China

While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may pose a risk of infection to people, as most anyone born after 1968 would likely be susceptib...

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Autores principales: Ma, Mai-Juan, Yang, Xiao-Xian, Qian, Yan-Hua, Zhao, Si-Yan, Hua, Sha, Wang, Tie-Cheng, Chen, Shan-Hui, Ma, Guang-Yuan, Sang, Xiao-Yu, Liu, Lin-Na, Wu, Ai-Ping, Jiang, Tai-Jiao, Gao, Yu-Wei, Gray, Gregory C., Zhao, Teng, Ling, Xia, Wang, Jing-Lin, Lu, Bing, Qian, Jun, Cao, Wu-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274511/
https://www.ncbi.nlm.nih.gov/pubmed/25533850
http://dx.doi.org/10.1038/srep07588
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author Ma, Mai-Juan
Yang, Xiao-Xian
Qian, Yan-Hua
Zhao, Si-Yan
Hua, Sha
Wang, Tie-Cheng
Chen, Shan-Hui
Ma, Guang-Yuan
Sang, Xiao-Yu
Liu, Lin-Na
Wu, Ai-Ping
Jiang, Tai-Jiao
Gao, Yu-Wei
Gray, Gregory C.
Zhao, Teng
Ling, Xia
Wang, Jing-Lin
Lu, Bing
Qian, Jun
Cao, Wu-Chun
author_facet Ma, Mai-Juan
Yang, Xiao-Xian
Qian, Yan-Hua
Zhao, Si-Yan
Hua, Sha
Wang, Tie-Cheng
Chen, Shan-Hui
Ma, Guang-Yuan
Sang, Xiao-Yu
Liu, Lin-Na
Wu, Ai-Ping
Jiang, Tai-Jiao
Gao, Yu-Wei
Gray, Gregory C.
Zhao, Teng
Ling, Xia
Wang, Jing-Lin
Lu, Bing
Qian, Jun
Cao, Wu-Chun
author_sort Ma, Mai-Juan
collection PubMed
description While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may pose a risk of infection to people, as most anyone born after 1968 would likely be susceptible to their infection. We report the isolation of a novel influenza A virus (H2N2) cultured in 2013 from a healthy domestic duck at a live poultry market in Wuxi City, China. Sequence data revealed that the novel H2N2 virus was similar to Eurasian avian lineage avian influenza viruses, the virus had been circulating for ≥ two years among poultry, had an increase in α2,6 binding affinity, and was not highly pathogenic. Approximately 9% of 100 healthy chickens sampled from the same area had elevated antibodies against the H2 antigen. Fortunately, there was sparse serological evidence that the virus was infecting poultry workers or had adapted to infect other mammals. These findings suggest that a novel H2N2 virus has been circulating among domestic poultry in Wuxi City, China and has some has increased human receptor affinity. It seems wise to conduct better surveillance for novel influenza viruses at Chinese live bird markets.
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spelling pubmed-42745112014-12-29 Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China Ma, Mai-Juan Yang, Xiao-Xian Qian, Yan-Hua Zhao, Si-Yan Hua, Sha Wang, Tie-Cheng Chen, Shan-Hui Ma, Guang-Yuan Sang, Xiao-Yu Liu, Lin-Na Wu, Ai-Ping Jiang, Tai-Jiao Gao, Yu-Wei Gray, Gregory C. Zhao, Teng Ling, Xia Wang, Jing-Lin Lu, Bing Qian, Jun Cao, Wu-Chun Sci Rep Article While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may pose a risk of infection to people, as most anyone born after 1968 would likely be susceptible to their infection. We report the isolation of a novel influenza A virus (H2N2) cultured in 2013 from a healthy domestic duck at a live poultry market in Wuxi City, China. Sequence data revealed that the novel H2N2 virus was similar to Eurasian avian lineage avian influenza viruses, the virus had been circulating for ≥ two years among poultry, had an increase in α2,6 binding affinity, and was not highly pathogenic. Approximately 9% of 100 healthy chickens sampled from the same area had elevated antibodies against the H2 antigen. Fortunately, there was sparse serological evidence that the virus was infecting poultry workers or had adapted to infect other mammals. These findings suggest that a novel H2N2 virus has been circulating among domestic poultry in Wuxi City, China and has some has increased human receptor affinity. It seems wise to conduct better surveillance for novel influenza viruses at Chinese live bird markets. Nature Publishing Group 2014-12-23 /pmc/articles/PMC4274511/ /pubmed/25533850 http://dx.doi.org/10.1038/srep07588 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Ma, Mai-Juan
Yang, Xiao-Xian
Qian, Yan-Hua
Zhao, Si-Yan
Hua, Sha
Wang, Tie-Cheng
Chen, Shan-Hui
Ma, Guang-Yuan
Sang, Xiao-Yu
Liu, Lin-Na
Wu, Ai-Ping
Jiang, Tai-Jiao
Gao, Yu-Wei
Gray, Gregory C.
Zhao, Teng
Ling, Xia
Wang, Jing-Lin
Lu, Bing
Qian, Jun
Cao, Wu-Chun
Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
title Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
title_full Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
title_fullStr Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
title_full_unstemmed Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
title_short Characterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
title_sort characterization of a novel reassortant influenza a virus (h2n2) from a domestic duck in eastern china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274511/
https://www.ncbi.nlm.nih.gov/pubmed/25533850
http://dx.doi.org/10.1038/srep07588
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