Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition

A new diabetic mouse strain, the Akita.PlGF knockout ((−/−)), was generated to study the role of placental growth factor (PlGF) in the pathogenesis of diabetic retinopathy (DR). PlGF deletion did not affect blood glucose but reduced the body weight of Akita.PlGF(−/−) mice. Diabetes-induced retinal c...

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Detalles Bibliográficos
Autores principales: Huang, Hu, He, Jianbo, Johnson, Da’Kuawn, Wei, Yanhong, Liu, Ying, Wang, Shuang, Lutty, Gerard A., Duh, Elia J., Semba, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274802/
https://www.ncbi.nlm.nih.gov/pubmed/25187372
http://dx.doi.org/10.2337/db14-0016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274802/
https://www.ncbi.nlm.nih.gov/pubmed/25187372
http://dx.doi.org/10.2337/db14-0016

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