Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a...

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Detalles Bibliográficos
Autores principales: Hwang, Joo-Yeon, Sim, Xueling, Wu, Ying, Liang, Jun, Tabara, Yasuharu, Hu, Cheng, Hara, Kazuo, Tam, Claudia H.T., Cai, Qiuyin, Zhao, Qi, Jee, Sunha, Takeuchi, Fumihiko, Go, Min Jin, Ong, Rick Twee Hee, Ohkubo, Takayoshi, Kim, Young Jin, Zhang, Rong, Yamauchi, Toshimasa, So, Wing Yee, Long, Jirong, Gu, Dongfeng, Lee, Nanette R., Kim, Soriul, Katsuya, Tomohiro, Oh, Ji Hee, Liu, Jianjun, Umemura, Satoshi, Kim, Yeon-Jung, Jiang, Feng, Maeda, Shiro, Chan, Juliana C.N., Lu, Wei, Hixson, James E., Adair, Linda S., Jung, Keum Ji, Nabika, Toru, Bae, Jae-Bum, Lee, Mi Hee, Seielstad, Mark, Young, Terri L., Teo, Yik Ying, Kita, Yoshikuni, Takashima, Naoyuki, Osawa, Haruhiko, Lee, So-Hyun, Shin, Min-Ho, Shin, Dong Hoon, Choi, Bo Youl, Shi, Jiajun, Gao, Yu-Tang, Xiang, Yong-Bing, Zheng, Wei, Kato, Norihiro, Yoon, Miwuk, He, Jiang, Shu, Xiao Ou, Ma, Ronald C.W., Kadowaki, Takashi, Jia, Weiping, Miki, Tetsuro, Qi, Lu, Tai, E Shyong, Mohlke, Karen L., Han, Bok-Ghee, Cho, Yoon Shin, Kim, Bong-Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274808/
https://www.ncbi.nlm.nih.gov/pubmed/25187374
http://dx.doi.org/10.2337/db14-0563
Descripción
Sumario:Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

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