Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a...

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Autores principales: Hwang, Joo-Yeon, Sim, Xueling, Wu, Ying, Liang, Jun, Tabara, Yasuharu, Hu, Cheng, Hara, Kazuo, Tam, Claudia H.T., Cai, Qiuyin, Zhao, Qi, Jee, Sunha, Takeuchi, Fumihiko, Go, Min Jin, Ong, Rick Twee Hee, Ohkubo, Takayoshi, Kim, Young Jin, Zhang, Rong, Yamauchi, Toshimasa, So, Wing Yee, Long, Jirong, Gu, Dongfeng, Lee, Nanette R., Kim, Soriul, Katsuya, Tomohiro, Oh, Ji Hee, Liu, Jianjun, Umemura, Satoshi, Kim, Yeon-Jung, Jiang, Feng, Maeda, Shiro, Chan, Juliana C.N., Lu, Wei, Hixson, James E., Adair, Linda S., Jung, Keum Ji, Nabika, Toru, Bae, Jae-Bum, Lee, Mi Hee, Seielstad, Mark, Young, Terri L., Teo, Yik Ying, Kita, Yoshikuni, Takashima, Naoyuki, Osawa, Haruhiko, Lee, So-Hyun, Shin, Min-Ho, Shin, Dong Hoon, Choi, Bo Youl, Shi, Jiajun, Gao, Yu-Tang, Xiang, Yong-Bing, Zheng, Wei, Kato, Norihiro, Yoon, Miwuk, He, Jiang, Shu, Xiao Ou, Ma, Ronald C.W., Kadowaki, Takashi, Jia, Weiping, Miki, Tetsuro, Qi, Lu, Tai, E Shyong, Mohlke, Karen L., Han, Bok-Ghee, Cho, Yoon Shin, Kim, Bong-Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274808/
https://www.ncbi.nlm.nih.gov/pubmed/25187374
http://dx.doi.org/10.2337/db14-0563
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author Hwang, Joo-Yeon
Sim, Xueling
Wu, Ying
Liang, Jun
Tabara, Yasuharu
Hu, Cheng
Hara, Kazuo
Tam, Claudia H.T.
Cai, Qiuyin
Zhao, Qi
Jee, Sunha
Takeuchi, Fumihiko
Go, Min Jin
Ong, Rick Twee Hee
Ohkubo, Takayoshi
Kim, Young Jin
Zhang, Rong
Yamauchi, Toshimasa
So, Wing Yee
Long, Jirong
Gu, Dongfeng
Lee, Nanette R.
Kim, Soriul
Katsuya, Tomohiro
Oh, Ji Hee
Liu, Jianjun
Umemura, Satoshi
Kim, Yeon-Jung
Jiang, Feng
Maeda, Shiro
Chan, Juliana C.N.
Lu, Wei
Hixson, James E.
Adair, Linda S.
Jung, Keum Ji
Nabika, Toru
Bae, Jae-Bum
Lee, Mi Hee
Seielstad, Mark
Young, Terri L.
Teo, Yik Ying
Kita, Yoshikuni
Takashima, Naoyuki
Osawa, Haruhiko
Lee, So-Hyun
Shin, Min-Ho
Shin, Dong Hoon
Choi, Bo Youl
Shi, Jiajun
Gao, Yu-Tang
Xiang, Yong-Bing
Zheng, Wei
Kato, Norihiro
Yoon, Miwuk
He, Jiang
Shu, Xiao Ou
Ma, Ronald C.W.
Kadowaki, Takashi
Jia, Weiping
Miki, Tetsuro
Qi, Lu
Tai, E Shyong
Mohlke, Karen L.
Han, Bok-Ghee
Cho, Yoon Shin
Kim, Bong-Jo
author_facet Hwang, Joo-Yeon
Sim, Xueling
Wu, Ying
Liang, Jun
Tabara, Yasuharu
Hu, Cheng
Hara, Kazuo
Tam, Claudia H.T.
Cai, Qiuyin
Zhao, Qi
Jee, Sunha
Takeuchi, Fumihiko
Go, Min Jin
Ong, Rick Twee Hee
Ohkubo, Takayoshi
Kim, Young Jin
Zhang, Rong
Yamauchi, Toshimasa
So, Wing Yee
Long, Jirong
Gu, Dongfeng
Lee, Nanette R.
Kim, Soriul
Katsuya, Tomohiro
Oh, Ji Hee
Liu, Jianjun
Umemura, Satoshi
Kim, Yeon-Jung
Jiang, Feng
Maeda, Shiro
Chan, Juliana C.N.
Lu, Wei
Hixson, James E.
Adair, Linda S.
Jung, Keum Ji
Nabika, Toru
Bae, Jae-Bum
Lee, Mi Hee
Seielstad, Mark
Young, Terri L.
Teo, Yik Ying
Kita, Yoshikuni
Takashima, Naoyuki
Osawa, Haruhiko
Lee, So-Hyun
Shin, Min-Ho
Shin, Dong Hoon
Choi, Bo Youl
Shi, Jiajun
Gao, Yu-Tang
Xiang, Yong-Bing
Zheng, Wei
Kato, Norihiro
Yoon, Miwuk
He, Jiang
Shu, Xiao Ou
Ma, Ronald C.W.
Kadowaki, Takashi
Jia, Weiping
Miki, Tetsuro
Qi, Lu
Tai, E Shyong
Mohlke, Karen L.
Han, Bok-Ghee
Cho, Yoon Shin
Kim, Bong-Jo
author_sort Hwang, Joo-Yeon
collection PubMed
description Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
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spelling pubmed-42748082016-01-01 Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians Hwang, Joo-Yeon Sim, Xueling Wu, Ying Liang, Jun Tabara, Yasuharu Hu, Cheng Hara, Kazuo Tam, Claudia H.T. Cai, Qiuyin Zhao, Qi Jee, Sunha Takeuchi, Fumihiko Go, Min Jin Ong, Rick Twee Hee Ohkubo, Takayoshi Kim, Young Jin Zhang, Rong Yamauchi, Toshimasa So, Wing Yee Long, Jirong Gu, Dongfeng Lee, Nanette R. Kim, Soriul Katsuya, Tomohiro Oh, Ji Hee Liu, Jianjun Umemura, Satoshi Kim, Yeon-Jung Jiang, Feng Maeda, Shiro Chan, Juliana C.N. Lu, Wei Hixson, James E. Adair, Linda S. Jung, Keum Ji Nabika, Toru Bae, Jae-Bum Lee, Mi Hee Seielstad, Mark Young, Terri L. Teo, Yik Ying Kita, Yoshikuni Takashima, Naoyuki Osawa, Haruhiko Lee, So-Hyun Shin, Min-Ho Shin, Dong Hoon Choi, Bo Youl Shi, Jiajun Gao, Yu-Tang Xiang, Yong-Bing Zheng, Wei Kato, Norihiro Yoon, Miwuk He, Jiang Shu, Xiao Ou Ma, Ronald C.W. Kadowaki, Takashi Jia, Weiping Miki, Tetsuro Qi, Lu Tai, E Shyong Mohlke, Karen L. Han, Bok-Ghee Cho, Yoon Shin Kim, Bong-Jo Diabetes Genetics/Genomes/Proteomics/Metabolomics Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation. American Diabetes Association 2015-01 2014-09-03 /pmc/articles/PMC4274808/ /pubmed/25187374 http://dx.doi.org/10.2337/db14-0563 Text en © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Genetics/Genomes/Proteomics/Metabolomics
Hwang, Joo-Yeon
Sim, Xueling
Wu, Ying
Liang, Jun
Tabara, Yasuharu
Hu, Cheng
Hara, Kazuo
Tam, Claudia H.T.
Cai, Qiuyin
Zhao, Qi
Jee, Sunha
Takeuchi, Fumihiko
Go, Min Jin
Ong, Rick Twee Hee
Ohkubo, Takayoshi
Kim, Young Jin
Zhang, Rong
Yamauchi, Toshimasa
So, Wing Yee
Long, Jirong
Gu, Dongfeng
Lee, Nanette R.
Kim, Soriul
Katsuya, Tomohiro
Oh, Ji Hee
Liu, Jianjun
Umemura, Satoshi
Kim, Yeon-Jung
Jiang, Feng
Maeda, Shiro
Chan, Juliana C.N.
Lu, Wei
Hixson, James E.
Adair, Linda S.
Jung, Keum Ji
Nabika, Toru
Bae, Jae-Bum
Lee, Mi Hee
Seielstad, Mark
Young, Terri L.
Teo, Yik Ying
Kita, Yoshikuni
Takashima, Naoyuki
Osawa, Haruhiko
Lee, So-Hyun
Shin, Min-Ho
Shin, Dong Hoon
Choi, Bo Youl
Shi, Jiajun
Gao, Yu-Tang
Xiang, Yong-Bing
Zheng, Wei
Kato, Norihiro
Yoon, Miwuk
He, Jiang
Shu, Xiao Ou
Ma, Ronald C.W.
Kadowaki, Takashi
Jia, Weiping
Miki, Tetsuro
Qi, Lu
Tai, E Shyong
Mohlke, Karen L.
Han, Bok-Ghee
Cho, Yoon Shin
Kim, Bong-Jo
Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
title Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
title_full Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
title_fullStr Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
title_full_unstemmed Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
title_short Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
title_sort genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in east asians
topic Genetics/Genomes/Proteomics/Metabolomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274808/
https://www.ncbi.nlm.nih.gov/pubmed/25187374
http://dx.doi.org/10.2337/db14-0563
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