Cargando…

Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells

Two new synthesized and characterized quinazoline Schiff bases 1 and 2 were investigated for anticancer activity against MCF-7 human breast cancer cell line. Compounds 1 and 2 demonstrated a remarkable antiproliferative effect, with an IC(50) value of 6.246 × 10(−6) mol/L and 5.910 × 10(−6) mol/L, r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faraj, Fadhil Lafta, Zahedifard, Maryam, Paydar, Mohammadjavad, Looi, Chung Yeng, Abdul Majid, Nazia, Ali, Hapipah Mohd, Ahmad, Noraini, Gwaram, Nura Suleiman, Abdulla, Mahmood Ameen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274848/ https://www.ncbi.nlm.nih.gov/pubmed/25548779 http://dx.doi.org/10.1155/2014/212096

Ejemplares similares

Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways
por: Zahedifard, Maryam, et al.
Publicado: (2015)

A Schiff Base-Derived Copper (II) Complex Is a Potent Inducer of Apoptosis in Colon Cancer Cells by Activating the Intrinsic Pathway
por: Hajrezaie, Maryam, et al.
Publicado: (2014)

Apoptotic effect of novel Schiff Based CdCl(2)(C(14)H(21)N(3)O(2)) complex is mediated via activation of the mitochondrial pathway in colon cancer cells
por: Hajrezaie, Maryam, et al.
Publicado: (2015)

Corrigendum: Apoptotic effect of novel Schiff Based CdCl(2)(C(14)H(21)N(3)O(2)) complex is mediated via activation of the mitochondrial pathway in colon cancer cells
por: Hajrezaie, Maryam, et al.
Publicado: (2017)

Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Copper (II) Complex against Ethanol-Induced Acute Gastric Lesions in Rats
por: Hajrezaie, Maryam, et al.
Publicado: (2012)

Gastroprotection Studies of Schiff Base Zinc (II) Derivative Complex against Acute Superficial Hemorrhagic Mucosal Lesions in Rats
por: Golbabapour, Shahram, et al.
Publicado: (2013)

N′-[1-(5-Bromo-2-hydroxyphenyl)ethylidene]-3,4,5-trihydroxybenzohydrazide dimethyl sulfoxide solvate trihydrate
por: Suleiman Gwaram, Nura, et al.
Publicado: (2010)

Chemopreventive Evaluation of a Schiff Base Derived Copper (II) Complex against Azoxymethane-Induced Colorectal Cancer in Rats
por: Hajrezaie, Maryam, et al.
Publicado: (2014)

Aqua{2-(morpholin-4-yl)-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}bis(thiocyanato-κN)manganese(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Bis(μ-2-{1-[2-(dimethylamino)ethylimino]ethyl}phenolato)bis[bromidocopper(II)] monohydrate
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

{N,N-Dimethyl-N′-[1-(2-pyridyl)ethylidene]ethane-1,2-diamine-κ(3) N,N′,N′′}bis(thiocyanato-κN)copper(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Dichlorido{N,N-dimethyl-N′-[1-(2-pyridyl)ethylidene]ethane-1,2-diamine-κ(3) N,N′,N′′}zinc
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Hexachloridobis{μ(2)-2-(piperazin-1-yl)-N-[1-(2-pyridyl)ethylidene]ethanamine}trizinc dihydrate
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

catena-Poly[[{N,N-dimethyl-N′-[1-(pyridin-2-yl)ethylidene]ethane-1,2-diamine-κ(3) N,N′,N′′}(thiocyanato-κN)cadmium]-μ-thiocyanato-κ(2) S:N]
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Diiodido{2-(morpholin-4-yl)-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}zinc
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

2,6-Diamino-4-oxo-3,4-dihydropyrimidin-1-ium chloride dihydrate
por: Suleiman Gwaram, Nura, et al.
Publicado: (2010)

[(1S,2S)-2-(1-{[2-(2-Oxidobenzylideneamino)cyclohexyl]imino}ethyl)phenolato-κ(4) O,N,N′,O′]copper(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2010)

Dichloridobis[2-(morpholin-4-yl)ethanamine-κ(2) N,N′]cadmium
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Dichlorido{N,N-dimethyl-N′-[1-(pyridin-2-yl)ethylidene]ethane-1,2-diamine-κ(3) N,N′,N′′}cadmium
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Dibromido{2-(morpholin-4-yl)-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}cadmium
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Dichlorido{2-(morpholin-4-yl)-N-[1-(pyridin-2-yl)ethylidene]ethanamine-κ(3) N,N′,N′′}copper(II) monohydrate
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway
por: Rouhollahi, Elham, et al.
Publicado: (2015)

Schiff Base Metal Derivatives Enhance the Expression of HSP70 and Suppress BAX Proteins in Prevention of Acute Gastric Lesion
por: Golbabapour, Shahram, et al.
Publicado: (2013)

Antibacterial Evaluation of Some Schiff Bases Derived from 2-Acetylpyridine and Their Metal Complexes
por: Gwaram, Nura Suleiman, et al.
Publicado: (2012)

Aqua{N,N-dimethyl-N′-[1-(2-pyridyl)ethylidene]ethane-1,2-diamine-κ(3) N,N′,N′′}bis(thiocyanato-κN)nickel(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Dichlorido{2-morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}cadmium
por: Ikmal Hisham, Nurulazimah, et al.
Publicado: (2010)

Dichlorido{2-morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}manganese(II)
por: Ikmal Hisham, Nurul Azimah, et al.
Publicado: (2010)

Dichlorido{2-morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}zinc(II)
por: Ikmal Hisham, Nurul Azimah, et al.
Publicado: (2010)

Di-μ-thiocyanato-κ(2) N:S;κ(2) S:N-bis({2-morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}(thiocyanato-κN)cadmium)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Aqua{2-morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}bis(thiocyanato-κN)cobalt(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

{2-Morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}bis(thiocyanato-κN)zinc(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2011)

Dichlorido{N,N-dimethyl-N′-[1-(2-pyridyl)ethylidene]ethane-1,2-diamine-κ(3) N,N′,N′′}manganese(II)
por: Ikmal Hisham, Nurul Azimah, et al.
Publicado: (2011)

Aqua{2-morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}bis(thiocyanato-κN)nickel(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2010)

Chlorido(2-{1-[(2-morpholinoethyl)imino]ethyl}phenolato-κ(3) N,N′,O)copper(II)
por: Ikmal Hisham, Nurul Azimah, et al.
Publicado: (2010)

{2-Morpholino-N-[1-(2-pyridyl)ethylidene]ethanamine-κ(3) N,N′,N′′}bis(thiocyanato-κN)copper(II)
por: Suleiman Gwaram, Nura, et al.
Publicado: (2010)

Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats
por: Hajrezaie, Maryam, et al.
Publicado: (2015)

Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G(0)/G(1) Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation
por: Narrima, Putri, et al.
Publicado: (2014)

A Zinc Morpholine Complex Prevents HCl/Ethanol-Induced Gastric Ulcers in a Rat Model
por: Salama, Suzy M., et al.
Publicado: (2016)

Biochanin A Gastroprotective Effects in Ethanol-Induced Gastric Mucosal Ulceration in Rats
por: Hajrezaie, Maryam, et al.
Publicado: (2015)

Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models
por: Paydar, Mohammadjavad, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lmkusejs6the9s9vasgcnrg7qe