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IGF-IR Targeted Therapy: Past, Present and Future

The IGF-I receptor (IGF-IR) has been studied as an anti-cancer target. However, monotherapy trials with IGF-IR targeted antibodies or with IGF-IR specific tyrosine kinase inhibitors have, overall, been very disappointing in the clinical setting. This review discusses potential reasons why IGF-I R ta...

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Detalles Bibliográficos
Autores principales:	Janssen, Joseph A. M. J. L., Varewijck, Aimee J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275034/ https://www.ncbi.nlm.nih.gov/pubmed/25566194 http://dx.doi.org/10.3389/fendo.2014.00224

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