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Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines
[Image: see text] A stereoselective cyclization between alkylidene oxindoles and 5-methoxyoxazoles has been developed using catalytic titanium(IV) chloride (as low as 5 mol %) to afford spiro[3,3′-oxindole-1-pyrrolines] in excellent yield (up to 99%) and diastereoselectivity (up to 99:1). Using a ch...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275133/ https://www.ncbi.nlm.nih.gov/pubmed/25474118 http://dx.doi.org/10.1021/ol5028128 |