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Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis

[Image: see text] Biochemical studies of purified and dissected fungal polyketide synthase and nonribosomal peptide synthetase (PKS-NRPS) hybrid enzymes involved in biosynthesis of pseurotin and aspyridone indicate that one α-methylation step during polyketide synthesis is a prerequisite and a key c...

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Detalles Bibliográficos
Autores principales:	Zou, Yi, Xu, Wei, Tsunematsu, Yuta, Tang, Mancheng, Watanabe, Kenji, Tang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275151/ https://www.ncbi.nlm.nih.gov/pubmed/25494235 http://dx.doi.org/10.1021/ol503179v

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