Lithium Diisopropylamide-Mediated Lithiation of 1,4-Difluorobenzene under Nonequilibrium Conditions: Role of Monomer-, Dimer-, and Tetramer-Based Intermediates and Lessons about Rate Limitation

[Image: see text] Lithiation of 1,4-difluorobenzene with lithium diisopropylamide (LDA) in THF at −78 °C joins the ranks of a growing number of metalations that occur under conditions in which the rates of aggregate exchanges are comparable to the rates of metalation. As such, a substantial number o...

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Detalles Bibliográficos
Autores principales: Liang, Jun, Hoepker, Alexander C., Bruneau, Angela M., Ma, Yun, Gupta, Lekha, Collum, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275155/
https://www.ncbi.nlm.nih.gov/pubmed/25000303
http://dx.doi.org/10.1021/jo501392r

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