SUMO Proteins are not Involved in TGF-β1-induced, Smad3/4-mediated Germline α Transcription, but PIASy Suppresses it in CH12F3-2A B Cells

TGF-β induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-β signal-transducing transcription factors, mediate germline (GL) α transcription induced by TGF-β1, resulting in IgA switching by mouse B cells. Post-translational sumoylation of Smad3 and Smad4 r...

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Detalles Bibliográficos
Autores principales: Lee, Sang-Hoon, Kim, Pyeung-Hyeun, Oh, Sang-Muk, Park, Jung-Hwan, Yoo, Yung-Choon, Lee, Junglim, Park, Seok-Rae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275389/
https://www.ncbi.nlm.nih.gov/pubmed/25550698
http://dx.doi.org/10.4110/in.2014.14.6.321

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