Cargando…

Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy

Understanding the signaling differences that distinguish human HER2-amplified (HER2-positive (HER2+)) breast cancers from other breast cancer subtypes may help to identify protein drug targets for the specific treatment of HER2+ breast cancers. We performed two kinome-wide small interfering RNA (siR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lapin, V, Shirdel, E A, Wei, X, Mason, J M, Jurisica, I, Mak, T W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275559/ https://www.ncbi.nlm.nih.gov/pubmed/25500906 http://dx.doi.org/10.1038/oncsis.2014.45

Ejemplares similares

A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment
por: Shen, Jing, et al.
Publicado: (2018)

Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells
por: Goan, Yih-Gang, et al.
Publicado: (2019)

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen
por: Jones, Nathaniel G., et al.
Publicado: (2014)

Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines
por: Kneissl, Julia, et al.
Publicado: (2016)

Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells
por: Tzeng, Yen-Dun Tony, et al.
Publicado: (2018)

Plant-Made Trastuzumab (Herceptin) Inhibits HER2/Neu+ Cell Proliferation and Retards Tumor Growth
por: Komarova, Tatiana V., et al.
Publicado: (2011)

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma
por: Read, Renee D., et al.
Publicado: (2013)

Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells
por: Baumann, Jan, et al.
Publicado: (2016)

The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2
por: Maadi, Hamid, et al.
Publicado: (2018)

Kinome-wide polypharmacology profiling of small molecules by multi-task graph isomorphism network approach
por: Bao, Lingjie, et al.
Publicado: (2023)

In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells
por: Ozbay, Tuba, et al.
Publicado: (2009)

Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines
por: Burguin, Anna, et al.
Publicado: (2020)

Trastuzumab-targeted gene delivery to Her2-overexpressing breast cancer cells
por: Mann, K, et al.
Publicado: (2016)

Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance
por: Upton, Rosalynd, et al.
Publicado: (2021)

Whole-transcriptome analysis links trastuzumab sensitivity of breast tumors to both HER2 dependence and immune cell infiltration
por: Triulzi, Tiziana, et al.
Publicado: (2015)

Time-Resolved Human Kinome RNAi Screen Identifies a Network Regulating Mitotic-Events as Early Regulators of Cell Proliferation
por: Zhang, Jitao David, et al.
Publicado: (2011)

Correction: Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines
Publicado: (2020)

NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs
por: Shirdel, Elize A., et al.
Publicado: (2011)

First Insight into the Kinome of Human Regulatory T Cells
por: König, Sebastian, et al.
Publicado: (2012)

Kinome-Wide siRNA Screening Identifies DYRK1B as a Potential Therapeutic Target for Triple-Negative Breast Cancer Cells
por: Chang, Chia-Che, et al.
Publicado: (2021)

Kinome-wide identification of phosphorylation networks in eukaryotic proteomes
por: Parca, Luca, et al.
Publicado: (2019)

High-Throughput Assessment of Kinome-wide Activation States
por: Schmidlin, Thierry, et al.
Publicado: (2019)

Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2
por: Wu, Yifen, et al.
Publicado: (2015)

The combination of gefitinib and RAD001 inhibits growth of HER2 overexpressing breast cancer cells and tumors irrespective of trastuzumab sensitivity
por: Dragowska, Wieslawa H, et al.
Publicado: (2011)

PI3K and MAPK Pathways as Targets for Combination with the Pan-HER Irreversible Inhibitor Neratinib in HER2-Positive Breast Cancer and TNBC by Kinome RNAi Screening
por: Lee, Jangsoon, et al.
Publicado: (2021)

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury
por: Kim, Ji Young, et al.
Publicado: (2020)

Kinome Profiling
por: Peppelenbosch, Maikel P.
Publicado: (2012)

Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers
por: Baldassarre, Tomas, et al.
Publicado: (2017)

CD4 T-cell immune stimulation of HER2 + breast cancer cells alters response to trastuzumab in vitro
por: Song, Patrick N., et al.
Publicado: (2020)

α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways
por: Mason, Julie K., et al.
Publicado: (2015)

Modulation of MicroRNA-194 and Cell Migration by HER2-Targeting Trastuzumab in Breast Cancer
por: Le, Xiao-Feng, et al.
Publicado: (2012)

Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells
por: Cheng, Peng, et al.
Publicado: (2015)

Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection
por: Prudêncio, Miguel, et al.
Publicado: (2008)

Kinome-Wide RNAi Screen Uncovers Role of Ballchen in Maintenance of Gene Activation by Trithorax Group in Drosophila
por: Khan, Muhammad Haider Farooq, et al.
Publicado: (2021)

Targeting HER2 in breast cancer: beyond trastuzumab
por: Winer, EP
Publicado: (2011)

Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2
por: Tobin, Steven J., et al.
Publicado: (2018)

A novel anti-HER2 antibody GB235 reverses Trastuzumab resistance in HER2-expressing tumor cells in vitro and in vivo
por: Shu, Mengjun, et al.
Publicado: (2020)

Combined kinome inhibition states are predictive of cancer cell line sensitivity to kinase inhibitor combination therapies
por: Joisa, Chinmaya U., et al.
Publicado: (2023)

Integrated single-dose kinome profiling data is predictive of cancer cell line sensitivity to kinase inhibitors
por: Joisa, Chinmaya U., et al.
Publicado: (2023)

In Vitro Cytotoxicity of Trastuzumab (Tz) and Se-Trastuzumab (Se-Tz) against the Her/2 Breast Cancer Cell Lines JIMT-1 and BT-474
por: Bapat, Priyanka, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cvplrjt7dtlp331fscsu5qgk2m